Streptomycin Side Effects Center

Last updated on RxList: 4/27/2021
Streptomycin Side Effects Center

What Is Streptomycin?

Streptomycin is an aminoglycoside antibiotic used with other medications to treat active tuberculosis (TB) infection if you cannot take other drugs for TB or if you have a type of TB that cannot be treated with other drugs (drug-resistant TB).

What Are Side Effects of Streptomycin?

Common side effects of Streptomycin include:

  • nausea,
  • vomiting,
  • stomach upset,
  • loss of appetite,
  • spinning sensation (vertigo),
  • injection site reactions (pain, irritation, and redness),
  • tingling or prickling sensation in the face,
  • rash,
  • fever,
  • hives, and
  • swelling (edema).

Tell your doctor if you have serious side effects of Streptomycin including:

  • muscle weakness,
  • persistent diarrhea even after stopping this medication,
  • easy bleeding or bruising,
  • fast heartbeat,
  • new signs of infections (e.g., high fever, persistent cough),
  • changes in the amount of urine, or
  • unusual tiredness.

Dosage for Streptomycin

Dosing of streptomycin is based on the patient's body weight. Treatment regimens vary.

What Drugs, Substances, or Supplements Interact with Streptomycin?

Streptomycin may interact with live bacterial vaccines, amphotericin B, diuretics, or high doses of aspirin/NSAIDs. If your doctor has directed you to take low doses of aspirin to prevent heart attack or stroke, you should continue to take the aspirin and consult your doctor. Tell your doctor all medications and supplements you use.

Streptomycin During Pregnancy or Breastfeeding

Streptomycin is not recommended for use during pregnancy. Some antibiotics may decrease the effectiveness of hormonal birth control; consult your doctor. This medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our streptomycin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Streptomycin Professional Information

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The following reactions are common: vestibular ototoxicity (nausea, vomiting, and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema; and eosinophilia.

The following reactions are less frequent: cochlear ototoxicity (deafness); exfoliative dermatitis; anaphylaxis; azotemia; leucopenia; thrombocytopenia; pancytopenia; hemolytic anemia; muscular weakness; and amblyopia.

Vestibular dysfunction resulting from the parenteral administration of streptomycin is cumulatively related to the total daily dose. When 1.8 to 2 g/day are given, symptoms are likely to develop in the large percentage of patients - especially in the elderly or patients with impaired renal function - within four weeks. Therefore, it is recommended that caloric and audiometric tests be done prior to, during, and following intensive therapy with streptomycin in order to facilitate detection of any vestibular dysfunction and/or impairment of hearing which may occur.

Vestibular symptoms generally appear early and usually are reversible with early detection and cessation of streptomycin administration. Two to three months after stopping the drug, gross vestibular symptoms usually disappear, except from the relative inability to walk in total darkness or on very rough terrain.

Although streptomycin is the least nephrotoxic of the aminoglycosides, nephrotoxicity does occur rarely.

Clinical judgment as to termination of therapy must be exercised when side effects occur.

Read the entire FDA prescribing information for Streptomycin (Streptomycin)


Digestive Disorders: Common Misconceptions See Slideshow

© Streptomycin Patient Information is supplied by Cerner Multum, Inc. and Streptomycin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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