[(E)-4-[(4-amino-2-methyl-pyrimidin-5-yl)methyl-formyl-amino]-3-[[(E)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl]-pent-3-enyl]-2-methylpropanoate, 2-Isobutyryl-thiamine Disulfide, Bis(2-(isobutyryloxy)ethyl-1-N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamido-2-propene-1-yl)disulfide; O-Isobutyrylthiamine Disulfide, Bisibuthiamine, Bisibutiamin, Bisibutiamine, Sulbuthiamine, Sulbutiamin, Sulbutiamina, Sulbutiamine, Sulbutiaminum, Vitaberin.
Sulbutiamine is man-made chemical similar to the B vitamin thiamine. Unlike thiamine, which dissolves in water, sulbutiamine dissolves in fats. Sulbutiamine is able to increase thiamine levels in the brain, and thought to be used as a stimulant in athletes.
How does it work?
It is not fully understood how sulbutiamine works. However, it seems to have various effects on the brain that might improve memory and reduce feelings of weakness.
Possibly Ineffective for...
- Fatigue caused by an infection. Early research suggests that taking sulbutiamine daily in addition to standard care for an infection over 15 days seems to help reduce weakness and fatigue in people with an infection. However, fatigue does not seem to improve when sulbutiamine is taken for longer periods of time. Other research shows that taking sulbutiamine daily for 28 days does not improve fatigue in people with an infection.
Insufficient Evidence to Rate Effectiveness for...
- Alzheimer's disease. Early research suggests that taking sulbutriamine by mouth for 3 months improves attention in people with early stage Alzheimer's disease. When it is combined with the anti-Alzheimer's drug donepezil (Aricept) for 3 months, it might also improve memory.
- Depression. Research suggests that taking sulbutriamine daily for 4 weeks improves one aspect of depression called psycho-behavioral inhibition, but no other measurements of depression.
- Diabetic nerve pain. Research suggests that taking sulbutiamine (Arcalion) daily for 6 weeks improves how well nerves work in people with nerve damage caused by diabetes. However, it does not seem to improve symptoms of diabetic nerve pain in these patients.
- Erectile dysfunction (ED). Early evidence shows that taking sulbutiamine for 30 days improves erectile dysfunction in 16 out of 20 men.
- Fatigue related to multiple sclerosis (MS). Early evidence suggests that taking sulbutiamine for 6 months improves fatigue related to multiple sclerosis.
- Athletic performance.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Sulbutiamine is POSSIBLY SAFE when taken by mouth appropriately, short-term. A dose of 600 mg daily has been used safely for up to 4 weeks. A small number of people taking sulbutiamine have reported nausea, headache, tiredness, and inability to sleep.
There isn't enough reliable information available about sulbutiamine to know if it is safe to use long-term.
Psychiatric disorders: People with certain psychiatric disorders, including bipolar disorder, may be more likely to abuse drugs. These individuals may be more likely to abuse sulbutiamine. Until more is known about sulbutiamine, people with psychiatric disorders should use sulbutiamine cautiously. These patients should not discontinue use of their prescribed treatments.
The appropriate dose of sulbutiamine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sulbutiamine (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Bettendorff L, Weekers L, Wins P, et al. Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissue. Biochem Pharmacol. 1990;40(11):2557-60. View abstract.
Bizot J, Herpin A, Pothion S, et al. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):928-35. View abstract.
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