Sutent vs. Cabometyx

Are Sutent and Cabometyx the Same Thing?

Sutent (sunitinib malate) and Cabometyx (cabozantinib) are kinase inhibitors used to treat advanced renal cell carcinoma.

What Are Possible Side Effects of Sutent?

Common side effects of Sutent include:

Side effects of Sutent include:

  • unusual or unpleasant taste in the mouth
  • cough
  • nausea
  • vomiting
  • upset stomach
  • constipation
  • dry skin
  • changes in skin or hair color (yellow skin or lighter skin/hair)
  • hair loss
  • joint pain
  • back pain
  • fatigue
  • tiredness
  • weakness
  • fever
  • diarrhea
  • mouth pain/sores
  • abdominal pain
  • rash or other skin changes such as dry or cracked skin
  • blisters or rash on hands or feet
  • loss of appetite
  • pain or swelling in the arms or legs
  • numbness or tingling of the arms or legs
  • shortness of breath
  • bleeding
  • watery eyes
  • swelling around the eyes
  • chest pain
  • general ill feeling, or
  • uneven heart rate.

Tell your doctor if you have serious side effects of Sutent including:

  • headache,
  • easy bruising or bleeding,
  • swelling ankles or feet,
  • unusual weight changes,
  • cold or heat intolerance,
  • unusual tiredness,
  • black or bloody stools,
  • vomit that looks like coffee grounds,
  • coughing up blood,
  • slow wound healing,
  • jaw pain,
  • toe/joint/back pain,
  • painful urination,
  • cloudy/pink/bloody urine,
  • changes in the amount of urine,
  • muscle weakness/cramping/twitching,
  • signs of low blood sugar (such as hunger, shakiness, fast heartbeat, sweating),
  • mental/mood changes (such as decreased alertness, irritability, nervousness), or
  • vision changes (such as decreased vision).

What Are Possible Side Effects of Cabometyx?

Common side effects of Cabometyx include:

  • diarrhea,
  • nausea,
  • vomiting,
  • swelling of the lips and mouth,
  • constipation,
  • abdominal pain indigestion,
  • fatigue,
  • weakness,
  • loss of appetite,
  • redness/swelling/pain on the palms of the hands and/or the soles of the feet,
  • rash,
  • dry skin,
  • high blood pressure,
  • weight loss,
  • changes in taste,
  • headache,
  • dizziness,
  • hypothyroidism,
  • difficulty speaking,
  • shortness of breath,
  • cough,
  • anemia,
  • pain in the extremities,
  • muscle spasms,
  • joint pain, and
  • high protein in the urine.

What Is Sutent?

Sutent (sunitinib malate) is a multi-kinase inhibitor indicated for the treatment of gastrointestinal stromal tumor after disease progression on, or intolerance to imatinib mesylate, for advanced renal cell carcinoma, and for progressive, well-differentiated pancreatic neuroendocrine tumors in patients with unresectable, locally advanced or metastatic disease. Sutent is available in generic form.

What Is Cabometyx?

Cabometyx (cabozantinib) Tablets is a kinase inhibitor indicated for the treatment of patients with advanced renal cell carcinoma (RCC) who have received prior anti-angiogenic therapy.

What Drugs Interact With Sutent?

Sutent may interact with dexamethasone, imatinib, isoniazid, nefazodone, St. John's wort, antibiotics, antifungals, barbiturates, heart or blood pressure medications, HIV/AIDS medicines, medicines to treat narcolepsy, medications to treat osteoporosis or Paget's disease of bone, seizure medications, or grapefruit and grapefruit juice. Tell your doctor all medications and supplements you use.

What Drugs Interact With Cabometyx?

Cabometyx may interact with antivirals, azole antifungals, macrolide antibiotics, conivaptan, grapefruit juice, nefazodone, rifampin, phenytoin, carbamazepine, phenobarbital, rifabutin, rifapentine, and St. John's Wort. Tell your doctor all medications and supplements you use.

How Should Sutent be Taken?

The recommended dose of Sutent (strengths available are 12.5, 25 and 50mg tablets). Sutent may be taken without food. Dose modification depends on the type of cancer treated and is determined by the treating doctor. Severe side effects include hepatotoxicity.

How Should Cabometyx be Taken?

The recommended daily dose of Cabometyx is 60 mg. Do not take Cabometyx with food.


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Pfizer. Sutent Product Information

Exelixis. Cabometyx Product Information.

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