How Do SV2A Ligands Work?

Reviewed on 9/7/2021

HOW DO SV2A LIGANDS WORK?

Synaptic vesicle protein 2A (SV2A) ligands are drugs used for treating different types of seizures. SV2A has been identified as the brain-binding site for seizure drugs.

SV2A ligands show high attraction to SV2A protein in the brain, which may contribute to its antiepileptic effect. This protein is present in almost all nerve cells. SV2A ligands bind to the SV2A protein to alter brain chemical release and facilitate inhibition of electrical impulse.

HOW ARE SV2A LIGANDS USED?

SV2A ligands are mainly used for treating:

  • Myoclonic seizures
  • Partial onset seizures
  • Primary generalized tonic-clonic seizures

WHAT ARE SIDE EFFECTS OF SV2A LIGANDS?

Some of the common side effects of SV2A ligands include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF SV2A LIGANDS?

Generic and brand names of SV2A ligands include:

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References
https://reference.medscape.com/drugs/sv2a-ligands

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