Symptom: Any subjective evidence of disease. In contrast, a sign is objective. Blood coming out a nostril is a sign; it is apparent to the patient, physician, and others. Anxiety, low back pain, and fatigue are all symptoms; only the patient can perceive them. From Healthy Resources Symptoms of Ankylosing Spondylitis Featured Centers Good and Bad Foods for PsoriasisVideo: Getting Personal on Life With MS Health Solutions From Our Sponsors Shot-Free MS Treatment Your Child and COVID-19