Synalar Side Effects Center

Last updated on RxList: 12/9/2020
Synalar Side Effects Center

What Is Synalar?

Synalar (fluocinolone acetonide) Cream is a topical (for the skin) steroid used to treat the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, seborrhea, and psoriasis. Synalar is available in generic form.

What Are Side Effects of Synalar?

Common side effects of Synalar Cream include:

  • stinging,
  • burning,
  • itching,
  • irritation,
  • dryness,
  • peeling, or
  • redness at the application site when this medication is first applied to the skin.

These side effects should disappear in a few days as your body adjusts to Synalar Cream. Other side effects of Synalar Cream include:

  • thinning or softening of your skin,
  • swollen hair follicles,
  • blisters,
  • pimples,
  • crusting of treated skin,
  • changes in color of treated skin,
  • skin rash or irritation around your mouth, or
  • stretch marks.

Skin infections can become worse when Synalar Cream is used. Notify your doctor if redness, swelling, or irritation does not improve.

Dosage for Synalar

Synalar Cream is generally applied to the affected area as a thin film in two to four times daily dosing depending on the severity of the condition.

What Drugs, Substances, or Supplements Interact with Synalar?

It is not likely that other drugs you take orally or inject will have an effect on topically applied Synalar. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use.

Synalar During Pregnancy and Breastfeeding

During pregnancy, Synalar should be used only when prescribed. It is unknown if this drug passes into breast milk when applied to the skin. Similar medications pass into breast milk when taken by mouth. Consult your doctor before breastfeeding.

Additional Information

Our Synalar (fluocinolone acetonide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Synalar Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • burning, itching, or irritation of treated skin;
  • increased hair growth;
  • white or "pruned" appearance of the skin;
  • rash, pimples; or
  • changes in color of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Synalar (Fluocinolone Acetonide)


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Synalar Professional Information


The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:

BurningHypertrichosisMaceration of the skin
ItchingAcneiform eruptionsSecondary infection
IrritationHypopigmentationSkin atrophy
DrynessPerioral dermatitisStriae
FolliculitisAllergic contact dermatitisMiliaria

Read the entire FDA prescribing information for Synalar (Fluocinolone Acetonide)

© Synalar Patient Information is supplied by Cerner Multum, Inc. and Synalar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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