Synera

Last reviewed on RxList: 1/12/2021
Synera Side Effects Center

What Is Synera?

Synera (lidocaine 70 mg and tetracaine 70 mg) Topical Patch contains a local anesthetic used on intact skin to provide local dermal analgesia for superficial venous access and superficial dermatological procedures such as excision, electrodessication and shave biopsy of skin lesions.

What Are Side Effects of Synera?

Common side effects of Synera include localized site reactions such as hives, blanching, swelling, abnormal sensation, rash, or skin discoloration. Systemic side effects of Synera are uncommon but may include:

Dosage for Synera

For adults and children 3 years of age and older, apply Synera to intact skin for 20-30 minutes as directed by a physician.

What Drugs, Substances, or Supplements Interact with Synera?

Synera may interact with antiarrhythmics, and other topical anesthetics. Tell your doctor all medications and supplements you use.

Synera During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before starting treatment with Synera. Lidocaine passes into breast milk and it is not known if tetracaine passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Synera (lidocaine 70 mg and tetracaine 70 mg) Topical Patch Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Synera Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers or call your doctor right away if you have:

  • severe burning, stinging, or other irritation where the medicine was applied;
  • sudden dizziness or drowsiness after the medicine is applied;
  • pale, gray, or blue colored skin;
  • headache, fast heartbeats, shortness of breath;
  • tiredness, or feeling like you might pass out;
  • blurred vision, ringing in your ears; or
  • unusual sensations of hot or cold.

Common side effects include:

  • skin redness;
  • skin swelling; or
  • changes in skin color where the medicine was applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Synera (Lidocaine and Tetracaine)

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Synera Professional Information

SIDE EFFECTS

Clinical Studies Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

Three different formulations were studied during clinical development of SYNERA: Developmental A (n=138), Developmental B (n=30), and the SYNERA final formulation (n=1281). The developmental patch formulations each contained the same amount of the active drug (70 mg each of lidocaine and tetracaine) as the final patch formulation, but varying amounts of excipients, principally polyvinyl alcohol and water. Data obtained from studies utilizing the developmental patches have been included in the overall evaluation of SYNERA safety (calculation of adverse event incidence).

Most common adverse events in clinical trials

Localized Reactions

During or immediately after treatment with SYNERA, the skin at the site of treatment may develop erythema, blanching, edema, or abnormal sensation. In clinical studies involving 1449 SYNERA-treated subjects, the most common local reactions were erythema (71%), blanching (12%) and edema (12%). These reactions were generally mild, resolving spontaneously soon after patch removal. There were no treatment-related serious adverse events.

Other application site reactions of various types (contact dermatitis, rash, skin discoloration) occurred in less than 4% of SYNERA-treated patients during clinical trials. Of these adverse events, 75% were mild, resolving spontaneously soon after patch removal.

Application site-related adverse events that occurred in 1% or less of SYNERA-treated subjects included rash, pruritus, pain, contact dermatitis, infection, skin discoloration, allergic reaction, blister, paresthesia, urticaria, and vesiculobullous rash.

Allergic Reactions

Allergic or anaphylactoid reactions can occur with the active or inactive components of SYNERA. They may be characterized by urticaria, angioedema, bronchospasm, and shock. Allergic reactions to the patch should be managed by conventional means.

Systemic (Dose-Related) Reactions

Systemic adverse reactions that occurred in 1% or less of SYNERA-treated subjects included dizziness, headache, nausea, somnolence, and vomiting. Systemic adverse effects of lidocaine and tetracaine are similar in nature to those observed with other amide and ester local anesthetic agents, including CNS excitation and/or depression (light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest). Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness merging into unconsciousness. Signs of CNS toxicity may start at plasma concentrations of lidocaine as low as 1000 ng/mL. The plasma concentrations at which tetracaine toxicity may occur are less well characterized; however, systemic toxicity with tetracaine is thought to occur with much lower plasma concentrations compared with lidocaine. The toxicity of co-administered local anesthetics is thought to be at least additive. Cardiovascular manifestations may include bradycardia, hypotension and cardiovascular collapse leading to arrest.

Read the entire FDA prescribing information for Synera (Lidocaine and Tetracaine)

© Synera Patient Information is supplied by Cerner Multum, Inc. and Synera Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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