Syringoma: A benign (noncancerous) skin tumor that derives from eccrine cells, specialized cells related to sweat glands. The skin lesions of syringoma usually appear during puberty or adult life, and consist of small bumps 1 to 3 mm in diameter that form under the surface of the skin. The most frequent site is the eyelids and around the eyes, but other areas of the body can also be affected. Syringomas more frequently affect women than men, and they have a hereditary basis in some cases. They are also associated with Down syndrome, Marfan syndrome, and Ehlers-Danlos syndrome.