Tabloid Side Effects Center

Last updated on RxList: 8/2/2021
Tabloid Side Effects Center

What Is Tabloid?

Tabloid (thioguanine 40-mg) is a cancer (antineoplastic) medication used to treat certain types of leukemia. Tabloid is sometimes given with other cancer medications. Tabloid may be available in generic form.

What Are Side Effects of Tabloid?

Common side effects of Tabloid include:

  • upset stomach
  • nausea
  • vomiting
  • diarrhea
  • hair loss
  • itching or skin rash, or
  • darkened skin color

Dosage for Tabloid

The dosage of Tabloid which will be tolerated and effective varies according to the stage and type of cancer being treated.

What Drugs, Substances, or Supplements Interact with Tabloid?

Tabloid may interact with acetaminophen (Tylenol), auranofin, azathioprine, cyclosporine, mercaptopurine, methotrexate, olsalazine, mesalamine, sulfasalazine, sulfamethoxazole and trimethoprim, birth control pills or hormone replacement therapy, blood thinners, tuberculosis medications, cholesterol medications, NSAIDs (nonsteroidal anti-inflammatory drugs), ACE inhibitors, antibiotics, antifungals, seizure medications, or HIV/AIDS medications. Tell your doctor all medications and supplements you use.

Tabloid During Pregnancy and Breastfeeding

Tabloid is not recommended for use during pregnancy. It may harm a fetus. Consult your doctor to discuss birth control. If you become pregnant or think you may be pregnant, tell your doctor. It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breastfeeding while using Tabloid is not recommended.

Additional Information

Our Tabloid (thioguanine 40-mg) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Tabloid Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using thioguanine and call your doctor if you have possible signs of liver damage:

  • stomach bloating, rapid weight gain;
  • unusual tiredness, trouble breathing while lying down;
  • nausea, loss of appetite, upper stomach pain; or
  • dark urine or jaundice (yellowing of the skin or eyes).

Call your doctor at once if you have:

  • easy bruising, unusual bleeding;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects may include:

  • fever, chills, or other signs of infection; or
  • high uric acid levels.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Tabloid Professional Information

SIDE EFFECTS

To report SUSPECTED ADVERSE REACTIONS, contact Aspen Global Inc. Toll-Free at 1-855-800-8165 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

The most frequent adverse reaction to thioguanine is myelosuppression. The induction of complete remission of acute myelogenous leukemia usually requires combination chemotherapy in dosages which produce marrow hypoplasia. Since consolidation and maintenance of remission are also effected by multiple-drug regimens whose component agents cause myelosuppression, pancytopenia is observed in nearly all patients. Dosages and schedules must be adjusted to prevent life-threatening cytopenias whenever these adverse reactions are observed.

Hyperuricemia frequently occurs in patients receiving thioguanine as a consequence of rapid cell lysis accompanying the antineoplastic effect. Adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as ZYLOPRIM® (allopurinol). Unlike PURINETHOL (mercaptopurine) and IMURAN® (azathioprine), thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation.

Less frequent adverse reactions include nausea, vomiting, anorexia, and stomatitis. Intestinal necrosis and perforation have been reported in patients who received multiple-drug chemotherapy including thioguanine.

Hepatic Effects

Liver toxicity associated with vascular endothelial damage has been reported when thioguanine is used in maintenance or similar long-term continuous therapy which is not recommended (see WARNINGS and DOSAGE AND ADMINISTRATION). This usually presents as the clinical syndrome of hepatic venoocclusive disease (hyperbilirubinemia, tender hepatomegaly, weight gain due to fluid retention, and ascites) or signs and symptoms of portal hypertension (splenomegaly, thrombocytopenia, and esophageal varices). Elevation of liver transaminases, alkaline phosphatase, and gamma glutamyl transferase and jaundice may also occur. Histopathological features associated with this toxicity include hepatoportal sclerosis, nodular regenerative hyperplasia, peliosis hepatitis, and periportal fibrosis.

Liver toxicity during short-term cyclical therapy presents as veno-occlusive disease. Reversal of signs and symptoms of this liver toxicity has been reported upon withdrawal of short-term or long-term continuous therapy.

Centrilobular hepatic necrosis has been reported in a few cases; however, the reports are confounded by the use of high doses of thioguanine, other chemotherapeutic agents, and oral contraceptives and chronic alcohol abuse.

DRUG INTERACTIONS

There is usually complete cross-resistance between PURINETHOL (mercaptopurine) and TABLOID brand Thioguanine.

As there is in vitro evidence that aminosalicylate derivatives (e.g., olsalazine, mesalazine, or sulphasalazine) inhibit the TPMT enzyme, they should be administered with caution to patients receiving concurrent thioguanine therapy (see WARNINGS).

Read the entire FDA prescribing information for Tabloid (Thioguanine)

© Tabloid Patient Information is supplied by Cerner Multum, Inc. and Tabloid Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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