- Are Protonix and Tagamet the Same Thing?
- What Are Possible Side Effects of Tagamet?
- What Are Possible Side Effects of Protonix?
- What Is Tagamet?
- What Is Protonix?
- What Drugs Interact with Tagamet?
- What Drugs Interact with Protonix?
- How Should Tagamet Be Taken?
- How Should Protonix Be Taken?
Are Tagamet and Protonix the Same Thing?
Tagamet (cimetidine) amd Protonix Delayed-Release Oral Suspension and Delayed-Release Tablets (pantoprazole sodium) are used to treat and prevent certain types of ulcer, to treat conditions that cause the stomach to produce too much acid, and to treat gastroesophageal reflux disease (GERD).
Protonix is also used to treat erosive esophagitis in adult patients, and it is intended for short-term treatment (less than 10 days).
Tagamet and Protonix belong to different drug classes. Tagamet is a histamine receptor antagonist and Protonix is a proton pump inhibitor (PPI).
Tagamet is available both over-the-counter (OTC) and as a generic.
Side effects of Tagamet and Protonix that are similar include headache, dizziness, drowsiness, joint pain, diarrhea, or nausea.
Side effects of Tagamet that are different from Protonix include depression, agitation, breast swelling or tenderness (in men), muscle pain, skin rash, or constipation.
Side effects of Protonix that are different from Tagamet include injection site reactions (redness, pain, swelling), vomiting, abdominal or stomach pain, gas, weight changes, tired feeling, or sleep problems (insomnia).
Both Tagamet and Protonix may interact with ketoconazole or blood thinners.
Tagamet may also interact with antacids or antidepressants.
Protonix may also interact with atazanavir, nelfinavir, ampicillin, digoxin, diuretics (water pills), iron, or methotrexate.
What Are Possible Side Effects of Tagamet?
Common side effects of Tagamet include:
- drowsiness,
- dizziness,
- weakness,
- blurred vision,
- dry eyes,
- dry mouth,
- vomiting,
- constipation,
- abdominal bloating,
- stuffy nose,
- sinus pain, or
- flushing (warmth, redness, or tingly feeling).
Tell your doctor if you experience unlikely but serious side effects of Tagamet Injection including:
- decreased sweating,
- fast/irregular heartbeat,
- mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement),
- difficulty urinating, or
- decreased sexual ability.
What Are Possible Side Effects of Protonix?
Common side effects of Protonix include:
- injection site reactions (redness, pain, swelling),
- headache,
- nausea,
- vomiting,
- abdominal or stomach pain,
- diarrhea,
- gas,
- dizziness,
- joint pain,
- weight changes,
- drowsiness,
- tired feeling, or
- sleep problems (insomnia).
What Is Tagamet?
Tagamet (cimetidine) is a histamine receptor antagonist used to treat and prevent certain types of ulcer, and to treat conditions that cause the stomach to produce too much acid. Tagamet is also used to treat gastroesophageal reflux disease (GERD), when stomach acid backs up into the esophagus and causes heartburn.
What Is Protonix?
Protonix IV (pantoprazole sodium) is a proton pump inhibitor (PPI) used for short-term treatment (less than 10 days) of gastroesophageal reflux disease (GERD) and a history of erosive esophagitis in adult patients.

SLIDESHOW
Digestive Disorders: Common Misconceptions See SlideshowWhat Drugs Interact With Tagamet?
Tagamet may interact with amantadine, quinidine, antihistamines, decongestants, appetite suppressants, phenothiazines, or antidepressants. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy, Tagamet should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
What Drugs Interact With Protonix?
Protonix may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, or methotrexate.
Protonix may also interact with nelfinavir, ampicillin, or iron.
How Should Tagamet Be Taken?
Dose of Tagamet depends on the condition being treated and the patient's response to the medication.
How Should Protonix Be Taken?
The recommended adult dose of Protonix is 40 mg once daily.
- Protonix Oral Suspension should be taken 30 minutes before a meal
- Protonix Oral Suspension should only be taken with applesauce or apple juice 30 minutes before a meal.
- Protonix Oral Suspension should not be taken in or with water or other liquids, or with other foods.
- Protonix Oral Suspension should not be chewed or crushed.
- Protonix Oral Suspension packet should not be divided to make a smaller dose.
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Prestige Consumer Healthcare. Tagamet Product Information.
https://www.tagamet.com/
FDA. Protonix Product Information.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020987s045lbl.pdf