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Tagamet vs. Protonix

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Tagamet and Protonix the Same Thing?

Tagamet (cimetidine) amd Protonix Delayed-Release Oral Suspension and Delayed-Release Tablets (pantoprazole sodium) are used to treat and prevent certain types of ulcer, to treat conditions that cause the stomach to produce too much acid, and to treat gastroesophageal reflux disease (GERD).

Protonix is also used to treat erosive esophagitis in adult patients, and it is intended for short-term treatment (less than 10 days).

Tagamet and Protonix belong to different drug classes. Tagamet is a histamine receptor antagonist and Protonix is a proton pump inhibitor (PPI).

Tagamet is available both over-the-counter (OTC) and as a generic.

Side effects of Tagamet and Protonix that are similar include headache, dizziness, drowsiness, joint pain, diarrhea, or nausea.

Side effects of Tagamet that are different from Protonix include depression, agitation, breast swelling or tenderness (in men), muscle pain, skin rash, or constipation.

Side effects of Protonix that are different from Tagamet include injection site reactions (redness, pain, swelling), vomiting, abdominal or stomach pain, gas, weight changes, tired feeling, or sleep problems (insomnia).

Both Tagamet and Protonix may interact with ketoconazole or blood thinners.

Tagamet may also interact with antacids or antidepressants.

Protonix may also interact with atazanavir, nelfinavir, ampicillin, digoxin, diuretics (water pills), iron, or methotrexate.

What Are Possible Side Effects of Tagamet?

Common side effects of Tagamet include:

Tell your doctor if you experience unlikely but serious side effects of Tagamet Injection including:

  • decreased sweating,
  • fast/irregular heartbeat,
  • mental/mood changes (such as confusion, hallucinations, agitation, nervousness, unusual excitement),
  • difficulty urinating, or
  • decreased sexual ability.

What Are Possible Side Effects of Protonix?

Common side effects of Protonix include:

  • injection site reactions (redness, pain, swelling),
  • headache,
  • nausea,
  • vomiting,
  • abdominal or stomach pain,
  • diarrhea,
  • gas,
  • dizziness,
  • joint pain,
  • weight changes,
  • drowsiness,
  • tired feeling, or
  • sleep problems (insomnia).

What Is Tagamet?

Tagamet Injection (glycopyrrolate) is an anticholinergic that helps to control conditions such as peptic ulcers that involve excessive stomach acid production. The injectable form of Tagamet is also used to reduce saliva, nasal, lung, and stomach secretions and to help control heart rate during surgery. Tagamet Injection is available in generic form.

What Is Protonix?

Protonix IV (pantoprazole sodium) is a proton pump inhibitor (PPI) used for short-term treatment (less than 10 days) of gastroesophageal reflux disease (GERD) and a history of erosive esophagitis in adult patients.

What Drugs Interact With Tagamet?

Tagamet may interact with amantadine, quinidine, antihistamines, decongestants, appetite suppressants, phenothiazines, or antidepressants. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy, Tagamet should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Protonix?

Protonix may interact with atazanavir, blood thinners, digoxin, diuretics (water pills), ketoconazole, or methotrexate.

Protonix may also interact with nelfinavir, ampicillin, or iron.

How Should Tagamet Be Taken?

Tagamet injection is administered intramuscularly (IM) or intravenously (IV), under a physician's supervision. Dose depends on the condition being treated.

How Should Protonix Be Taken?

The recommended adult dose of Protonix is 40 mg once daily.

  • Protonix Oral Suspension should be taken 30 minutes before a meal
  • Protonix Oral Suspension should only be taken with applesauce or apple juice 30 minutes before a meal.
  • Protonix Oral Suspension should not be taken in or with water or other liquids, or with other foods.
  • Protonix Oral Suspension should not be chewed or crushed.
  • Protonix Oral Suspension packet should not be divided to make a smaller dose.
Reviewed on 4/15/2019


Prestige Consumer Healthcare. Tagamet Product Information.

FDA. Protonix Product Information.


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