Talacen Side Effects Center

Last updated on RxList: 11/16/2022
Talacen Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Talacen?

Talacen (pentazocine and acetaminophen) is a pain medication used to treat mild to moderate pain. Talacen is available in generic form.

What Are Side Effects of Talacen?

Talacen may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • mood changes,
  • agitation,
  • hallucinations,
  • confusion,
  • difficulty urination,
  • vision changes,
  • fast heartbeat,
  • changes in the amount of urine,
  • fever,
  • sore throat,
  • easy bruising,
  • unusual bleeding,
  • fainting,
  • slow or shallow breathing,
  • seizures, and
  • severe dizziness

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Talacen include:

  • nausea
  • vomiting
  • upset stomach,
  • diarrhea
  • constipation
  • lightheadedness
  • dizziness
  • drowsiness
  • increased sweating
  • dry mouth
  • headache, and
  • blurred vision.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Talacen

The recommended dosage of Talacen is 1 caplet every 4 hours as needed for pain relief.

What Drugs, Substances, or Supplements Interact with Talacen?

Robinul, Cantil, Narcan, Dramamine, bladder or urinary medications, bronchodilators, irritable bowel medications, Anergan, Furoxone, Tylenol or other drugs that contain acetaminophen may interact with Talacen. Tell your doctor all medications you take. Avoid alcohol while taking Talacen. Do not drive, use machinery, or do any activity that requires alertness when taking Talacen.

Talacen During Pregnancy or Breastfeeding

If you are pregnant only take Talacen if the potential benefits outweigh the potential risk to the fetus. Exercise caution if you take Talacen and are breastfeeding.

Additional Information

Our Talacen (pentazocine hydrochloride, USP, and acetaminophen, USP) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Clinical experience with TALACEN has been insufficient to define all possible adverse reactions with this combination. However, reactions reported after oral administration of pentazocine hydrochloride in 50 mg dosage include the following:

Cardiovascular: hypertension, hypotension, circulatory depression, tachycardia.

Respiratory: rarely respiratory depression,

Acute CNS Manifestations: Hallucinations (usually visual), disorientation, and confusion

Other CNS effects: grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.

Autonomic: sweating; infrequently flushing; and rarely chills.

Gastrointestinal: nausea, vomiting, constipation; diarrhea, anorexia, dry mouth, Biliary tract spasm, and rarely abdominal distress.

Allergic: edema of the face, anaphylactic shock, dermatitis including pruritus, flushed skin including plethora, infrequently rash; and rarely urticaria.

Ophthalmic: visual blurring and focusing difficulty, miosis.

Hematologic: depression of white blood cells (especially granulocytes) with rare cases of agranulocytosis, which is usually reversible, moderate transient eosinophilia.

Dependence and Withdrawal Symptoms: (See WARNINGS, PRECAUTIONS, and Drug Abuse And Dependence Sections).

Other: urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson Syndrome, toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.

Numerous clinical studies have shown that acetaminophen, when taken in recommended doses, is relatively free of adverse effects in most age groups, even in the presence of a variety of disease states.

A few cases of hypersensitivity to acetaminophen have been reported, as manifested by skin rashes, thrombocytopenic purpura, rarely hemolytic anemia and agranulocytosis. Occasional individuals respond to ordinary doses with nausea and vomiting and diarrhea.

Read the entire FDA prescribing information for Talacen (Pentazocine and Acetaminophen Tablets)


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© Talacen Patient Information is supplied by Cerner Multum, Inc. and Talacen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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