Taltz vs. Stelara

Are Taltz and Stelara the Same Thing?

Taltz (ixekizumab) injection and Stelara (ustekinumab) injection are monoclonal antibodies used to treat plaque psoriasis.

Side effects of Taltz and Stelara that are similar include injection site reactions (bruising, itching, pain, redness, swelling, and hardening of the skin) and cold symptoms (runny or stuffy nose, sneezing, sore throat).

Side effects of Taltz that are different from Stelara include nausea and fungal infections (ringworm, athlete's foot and jock itch).

Side effects of Stelara that are different from Taltz include headache, tired feeling, diarrhea, and skin rash or itching.

Both Taltz and Stelara may interact with "live" vaccines.

Taltz may also interact with warfarin and cyclosporine.

What Are Possible Side Effects of Taltz?

Common side effects of Taltz include:

  • injection site reactions (redness, pain)
  • upper respiratory tract infections (runny or stuffy nose, rhinovirus infections)
  • nausea, and
  • fungal infections (ringworm, athlete's foot and jock itch)

What Are Possible Side Effects of Stelara?

Common side effects of Stelara include:

  • injection site reactions (bruising, itching, pain, redness, swelling, and hardening of the skin),
  • cold symptoms (stuffy nose, sneezing, sore throat),
  • headache,
  • tired feeling,
  • diarrhea, or
  • skin rash or itching.

Stelara can affect your immune system and can lower your body's ability to fight an infection. Tell your doctor if you develop signs of an infection, such as worsening redness/swelling/tenderness at the injection site after 2 days, fever or chills, cold or flu symptoms, severe stomach pain, or persistent nausea or vomiting.

What Is Taltz?

Taltz (ixekizumab) injection is a humanized interleukin-17A antagonist indicated for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

What Is Stelara?

Stelara (ustekinumab) Injection is a monoclonal antibody used to treat plaque psoriasis.

What Drugs Interact With Taltz?

Taltz may interact with "live" vaccines, warfarin, and cyclosporine. Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Stelara?

Live vaccines such as the polio and flu vaccine may interact with Stelara. Tell your doctor all medications you use, all recent vaccines you have received, and all infections you have had. Stelara may weaken your body's ability to fight infections. If you are pregnant only take Stelara if clearly needed. Exercise caution if you are taking Stelara and are breastfeeding.


Types of Psoriasis: Medical Pictures and Treatments See Slideshow

How Should Taltz be Taken?

The recommended dose of Taltz is 160 mg (two 80 mg injections) at Week 0, followed by 80 mg at Weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks.

How Should Stelara be Taken?

The recommended dosage of Stelara is either 45 mg or 90 mg given on day one, then 4 weeks later, and every 12 weeks thereafter.


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Lilly. Taltz Product Information.


Janssen Biotech. Stelara Product Information.


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