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Talwin Nx

Last reviewed on RxList: 2/10/2017
Talwin Nx Side Effects Center

Last reviewed on RxList 12/1/2016

Talwin Nx (pentazocine hydrochloride and naloxone hydrochloride) is a combination of a narcotic pain reliever (opiate-type) and an opioid antagonist used to treat moderate to severe pain. Common side effects of Talwin Nx include:

Tell your doctor if you have serious side effects of Talwin Nx including:

The dosage is based on the individual patient's medical condition and response to treatment. Talwin Nx may adversely interact with naltrexone, sibutramine, fluoxetine, MAO inhibitors, alcohol, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, psychiatric medicines or any medication that may cause drowsiness or affect breathing. During pregnancy, this medication should be used only when prescribed. Using it near the expected delivery date is not recommended because of possible harm to the fetus. Discuss the risks and benefits with your doctor. Infants born to mothers who have used this medication may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor immediately if you notice any of these symptoms in your newborn. It is unknown if this product passes into breast milk. Discuss the risks and benefits with your doctor before breastfeeding. Do not stop using Talwin Nx suddenly after long-term use, or you could have withdrawal symptoms.

Our Talwin Nx Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Talwin Nx Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • weak or shallow breathing, slow heartbeats;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe weakness or dizziness;
  • seizure (convulsions);
  • feeling like you might pass out; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • dizziness, drowsiness;
  • headache, weakness;
  • feeling restless or irritable;
  • diarrhea, constipation;
  • dry mouth, nausea, vomiting, loss of appetite;
  • tremor, chills, sweating;
  • flushing (warmth, redness, or tingly feeling);
  • sleep problems (insomnia), strange dreams;
  • blurred vision; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Talwin Nx (Pentazocine and Naloxone)

Talwin Nx Professional Information



Hypertension, hypotension, circulatory depression, tachycardia, syncope.


Rarely, respiratory depression.

Acute CNS Manifestations

Hallucinations (usually visual), disorientation, and confusion .

Other CNS Effects

Grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.


Sweating; infrequently flushing; and rarely chills.


Nausea, vomiting, constipation, diarrhea, anorexia, dry mouth, biliary tract spasm, and rarely abdominal distress.


Edema of the face; anaphylactic shock; dermatitis, including pruritus; flushed skin, including plethora; infrequently rash, and rarely urticaria.


Visual blurring and focusing difficulty, miosis.


Depression of white blood cells (especially granulocytes), with rare cases of agranulocytosis, which is usually reversible, moderate transient eosinophilia.

Dependence and Withdrawal Symptoms

(See WARNINGS, PRECAUTIONS, and Drug Abuse and DependenceSections).


Urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson syndrome toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.

Read the entire FDA prescribing information for Talwin Nx (Pentazocine and Naloxone)

Related Resources for Talwin Nx

Read the Talwin Nx User Reviews »

© Talwin Nx Patient Information is supplied by Cerner Multum, Inc. and Talwin Nx Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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