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Last reviewed on RxList: 3/20/2020
Talzenna Patient Information Including Side Effects

Brand Names: Talzenna

Generic Name: talazoparib

What is talazoparib (Talzenna)?

Talazoparib is used to treat HER2-negative breast cancer that has spread to other parts of the body.

Talazoparib is used only if your cancer has a specific genetic marker (an abnormal "BRCA" gene). Your doctor will test you for this gene.

Talazoparib may also be used for purposes not listed in this medication guide.

What are the possible side effects of talazoparib (Talzenna)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blood in your urine or stools;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • weight loss;
  • low red blood cells (anemia)--pale skin, weakness, feeling tired or short of breath, cold hands and feet; or
  • low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects may include:

  • low blood cell counts;
  • nausea, vomiting, diarrhea, loss if appetite;
  • hair loss;
  • headache; or
  • feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about talazoparib (Talzenna)?

Using talazoparib may increase your risk of developing bone marrow problems or leukemia.

Talazoparib can lower your blood cell counts, and you may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, blood in your urine or stools, weight loss, fever, weakness, tiredness, or trouble breathing.

You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.


Breast Cancer Awareness: Symptoms, Diagnosis, and Treatment See Slideshow
Talzenna Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking talazoparib (Talzenna)?

Tell your doctor if you have ever had:

  • kidney disease.

Using talazoparib may increase your risk of developing bone marrow problems or leukemia. Ask your doctor about this risk.

You may need to have a negative pregnancy test before starting this treatment.

Talazoparib can harm an unborn baby or cause a miscarriage if the mother or the father is using this medicine.

  • If you are a woman, do not use talazoparib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using talazoparib.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because talazoparib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 month after your last dose.

How should I take talazoparib (Talzenna)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take talazoparib with or without food.

Swallow the capsule whole and do not dissolve or open it.

If you vomit shortly after taking talazoparib, do not take another dose. Wait until your next scheduled dose time to take the medicine again.

Talazoparib is usually given until your body no longer responds to the medication.

Talazoparib can lower your blood cell counts, and you may get an infection or bleed more easily. You will need weekly or monthly blood tests, and your cancer treatments may be delayed based on the results.

Store at room temperature away from moisture and heat.

You should not stop using talazoparib without first asking your doctor.


A lump in the breast is almost always cancer. See Answer
Talzenna Patient Information including If I Miss a Dose

What happens if I miss a dose (Talzenna)?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose (Talzenna)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking talazoparib (Talzenna)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect talazoparib (Talzenna)?

Tell your doctor about all your other medicines, especially:

  • amiodarone;
  • carvedilol;
  • clarithromycin;
  • itraconazole; or
  • verapamil.

Other drugs may affect talazoparib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information (Talzenna)?

Your pharmacist can provide more information about talazoparib.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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