Targretin Gel

Last updated on RxList: 07/12/2021
Targretin Gel Patient Information Including Side Effects

Brand Names: Targretin Topical

Generic Name: bexarotene (topical)

What is bexarotene topical (Targretin Topical)?

Bexarotene topical (for the skin) is used to treat skin lesions caused by a rare type of cancer called cutaneous T-cell lymphoma. Bexarotene is usually given after other treatments have failed.

Bexarotene topical may also be used for purposes not listed in this medication guide.

What are the possible side effects of bexarotene topical (Targretin Topical)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using bexarotene topical and call your doctor at once if you have severe skin irritation (rash, itching, burning, redness, scaling) after applying the medicine.

Common side effects may include:

  • mild rash, itching, or skin irritation; or
  • skin dryness or peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about bexarotene topical (Targretin Topical)?

Bexarotene can harm an unborn baby or cause birth defects if the mother or the father is using this medicine. Do not use bexarotene if you are pregnant.

Both men and women using bexarotene should use effective birth control to prevent pregnancy, beginning 1 month before starting and continuing until at least 1 month after stopping treatment.

Stop using this medicine and tell your doctor right away if you stop using birth control, if you miss a menstrual period, or if a pregnancy occurs while either the mother or the father is using bexarotene.

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Targretin Gel Patient Information including How Should I Take

What should I discuss with my healthcare provider before using bexarotene topical (Targretin Topical)?

You should not use bexarotene if you are allergic to it, or if you are pregnant.

Tell your doctor if you have ever had:

Bexarotene can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

If you are a man, use condoms during sex if your partner is pregnant or is able to get pregnant. Keep using condoms while using bexarotene and for at least 1 month after your last dose.

If you are a woman, do not use bexarotene if you are pregnant or plan to become pregnant. You must have a negative pregnancy test 7 days before you start using bexarotene and once per month during treatment.

  • You should start using bexarotene on the 2nd or 3rd day of a normal menstrual period.
  • Use 2 effective forms of birth control beginning 1 month before you start using bexarotene, and continuing until at least 1 month after your last dose.
  • At least one of your forms of birth control should be non-hormonal such as a condom, cervical cap, contraceptive sponge, IUD, or diaphragm with spermicide.
  • Stop using bexarotene and tell your doctor right away if you stop using birth control, or if you miss a menstrual period.

If a pregnancy occurs while either the mother or the father is using bexarotene, stop using the medicine and tell your doctor right away.

You should not breastfeed while you are using bexarotene topical.

How should I use bexarotene topical (Targretin Topical)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Bexarotene topical is usually applied once every other day for the first week and gradually increased until you are applying the medicine 4 times every day. Follow your doctor's dosing instructions very carefully.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Wash your hands before and after using bexarotene topical, unless you are using the medication to treat the skin on your hands.

Apply only enough gel to cover each lesion. Do not cover the treated skin with a bandage.

Avoid getting this medicine in your eyes, mouth, or nose, or on healthy skin. If this does happen, rinse or wash off the medicine.

You may need to stop using bexarotene for a short time if you have severe skin irritation.

Store at room temperature away from moisture, heat, and light.

It may take several weeks or months before you receive the full benefit of this medicine. Your doctor will determine how long to treat you.

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Targretin Gel Patient Information including If I Miss a Dose

What happens if I miss a dose (Targretin Topical)?

Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.

What happens if I overdose (Targretin Topical)?

An overdose of bexarotene topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using bexarotene topical (Targretin Topical)?

Grapefruit may interact with bexarotene and lead to unwanted side effects. Avoid the use of grapefruit products.

Avoid taking a vitamin A supplement without your doctor's advice. Use only the amount your doctor recommends.

Bexarotene topical could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Avoid using other medications on the areas you treat with bexarotene topical unless your doctor tells you to.

Do not use insect repellents or other products that contain DEET (N,N-diethyl-m-toluamide) while using bexarotene topical. Bexarotene may increase DEET toxicity, which could be dangerous.

What other drugs will affect bexarotene topical (Targretin Topical)?

Tell your doctor about all your current medicines. Many drugs can affect bexarotene, especially:

This list is not complete and many other drugs may affect bexarotene. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Targretin Topical)?

Your doctor or pharmacist can provide more information about bexarotene topical.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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