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Tazorac

Last reviewed on RxList: 6/16/2017
Tazorac Side Effects Center

Last reviewed on RxList 6/16/2017

Tazorac (tazarotene) Gel is a compound similar to vitamin A used to treat plaque psoriasis (psoriasis with scaly patches) and to treat facial acne. The Avage brand of tazarotene cream is used to reduce the appearance of fine wrinkles on the face, mottled light and dark skin patches on the face, and benign facial lentigines (noncancerous freckles). Common side effects of Tazorac Gel include:

  • itching,
  • redness,
  • irritation,
  • burning/stinging,
  • scaling,
  • dry skin,
  • peeling, or
  • pain at application site, and
  • skin sensitivity to sunlight.

Tell your doctor if you have serious side effects of Tazorac Gel including:

  • severe skin irritation (burning, stinging, itching) after application;
  • severe redness or discomfort; or
  • swelling, warmth, oozing, or other signs of skin infection.

To treat psoriasis, the recommended starting dose of Tazorac is 0.05% gel, with strength increased to 0.1% if tolerated and indicated. Apply a dose of Tazorac Gel once a day, in the evening, to psoriatic lesions, using enough (2 mg/cm�) to cover only the lesion with a thin film to no more than 20% of body surface area. To treat acne, after cleansing the face, apply a thin film dose of Tazorac Gel 0.1% (2 mg/cm�) once a day, in the evening, to the skin where acne lesions appear. Tazorac may interact with other topical products that have a drying effect, diuretics, antibiotics, or phenothiazines. Tell your doctor all medications and supplements you use. Tazorac must not be used during pregnancy. It may harm a fetus. If you become pregnant or think you may be pregnant, inform your doctor. Women should have a negative pregnancy test within 2 weeks of starting this medication and also start this medication during their normal period. It is recommended that men and women using this medication use two forms of birth control (e.g., condoms and birth control pills) while taking this medication; consult your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Tazorac (tazarotene) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tazorac Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using tazarotene topical and call your doctor at once if you have a serious side effect such as:

  • severe skin irritation (burning, stinging, itching) after applying this medication;
  • severe redness or discomfort; or
  • swelling, warmth, oozing, or other signs of skin infection.

Less serious side effects may include:

  • mild burning, stinging, or itching;
  • mild pain, redness, or irritation; or
  • skin dryness or peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tazorac (Tazarotene Gel)

Tazorac Professional Information

SIDE EFFECTS

In human dermal safety studies, tazarotene 0.05% and 0.1% gels did not induce allergic contact sensitization, phototoxicity or photoallergy.

Psoriasis

The most frequent adverse events reported with TAZORAC® (tazarotene gel) Gel 0.05% and 0.1% were limited to the skin. Those occurring in 10 to 30% of patients, in descending order, included pruritus, burning/stinging, erythema, worsening of psoriasis, irritation, and skin pain. Events occurring in 1 to 10% of patients included rash, desquamation, irritant contact dermatitis, skin inflammation, fissuring, bleeding, and dry skin. Increases in “psoriasis worsening” and “sun-induced erythema” were noted in some patients over the 4th to 12th months as compared to the first three months of a 1 year study. In general, the incidence of adverse events with TAZORAC® (tazarotene gel) Gel 0.05% was 2 to 5% lower than that seen with TAZORAC® (tazarotene gel) Gel 0.1%.

Acne

The most frequent adverse events reported with TAZORAC® (tazarotene gel) Gel 0.1% in the treatment of acne occurring in 10 to 30% of patients, in descending order, included desquamation, burning/stinging, dry skin, erythema and pruritus. Events occurring in 1 to 10% of patients included irritation, skin pain, fissuring, localized edema and skin discoloration.

Postmarketing Experience

The following adverse reactions have been identified during postmarketing use of TAZORAC® (tazarotene gel) Gel 0.05% and 0.1% in clinical practice. Because they are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to TAZORAC® (tazarotene gel) Gel. The reactions include: blister, rash, skin discoloration (including skin hyperpigmentation or skin hypopigmentation), and pain.

Read the entire FDA prescribing information for Tazorac (Tazarotene Gel)

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