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Tegretol vs. Gabapentin (Neurontin, Gralise, Horizant)

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Tegretol and Neurontin, Gralise, Horizant the Same Thing?

Tegretol (carbamazepine) and gabapentin are anti-epileptic medications used to treat seizures and nerve pain due to different causes.

Tegretol such as nerve pain due to trigeminal neuralgia and diabetic neuropathy and gabapentin is used to treat nerve pain caused by shingles (herpes zoster).

Tegretol is also used to treat bipolar disorder.

Brand names for gabapentin include Neurontin, Gralise, and Horizant.

Side effects of Tegretol and gabapentin that are similar include dizziness, drowsiness, loss of balance or coordination, or unsteadiness.

Side effects of Tegretol that are different from gabapentin include nausea, vomiting, dry mouth, or swollen tongue.

Side effects of gabapentin that are different from Tegretol include memory loss, difficulty speaking, viral infections, tremors, double vision, fever, unusual eye movements, jerky movements, mood or behavior changes, depression, or anxiety.

Tegretol may interact with theophylline, birth control pills or hormone replacement therapy, antibiotics, drugs to treat tuberculosis, antifungal medications, blood thinners, cancer medicines, heart or blood pressure medications, HIV or AIDS medications, medications to treat depression or mental illness, medicines to prevent organ transplant rejection, other seizure medications, steroids, or thyroid replacement medications.

Gabapentin may interact with antacids, alcohol, hydrocodone, morphine, and naproxen.

You may have increased seizures or unpleasant withdrawal symptoms if you stop using Tegretol suddenly.

What Are Possible Side Effects of Tegretol?

Common side effects of Tegretol include:

  • nausea,
  • vomiting,
  • dizziness,
  • drowsiness,
  • dry mouth,
  • swollen tongue,
  • loss of balance or coordination, or
  • unsteadiness.

What Are Possible Side Effects of Neurontin, Gralise, Horizant?

Common side effects of Neurontin, Gralise, Horizant include:

  • dizziness,
  • drowsiness,
  • unsteadiness,
  • memory loss,
  • lack of coordination,
  • difficulty speaking,
  • viral infections,
  • tremors,
  • double vision,
  • fever,
  • unusual eye movements, and
  • jerky movements.

What Is Tegretol?

Tegretol (carbamazepine) is an anticonvulsant used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy. Tegretol is also used to treat bipolar disorder. Tegretol is available in generic form.

What Is Neurontin, Gralise, Horizant?

Neurontin, Gralise, Horizant (phenytoin) is a prescription medicine used to treat:

  • Pain from damaged nerves (postherpetic pain) that follows healing of shingles (a painful rash that comes after a herpes zoster infection) in adults.
  • Partial seizures when taken together with other medicines in adults and children 3 years of age and older with seizures.

What Drugs Interact With Tegretol?

Tegretol may interact with other seizure medications, HIV or AIDS medications, antibiotics, antidepressants, medications to treat mental illness, or blood thinners.

Tegretol may also interact with theophylline, birth control pills or hormone replacement therapy, drugs to treat tuberculosis, antifungal medications, cancer medicines, heart or blood pressure medications, medicines to prevent organ transplant rejection, steroids, or thyroid replacement medications.

You may have increased seizures or unpleasant withdrawal symptoms if you stop using Tegretol suddenly.

What Drugs Interact With Neurontin, Gralise, Horizant?

Do not take Neurontin, Gralise, Horizant if you are allergic to gabapentin or any of the other ingredients in

Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking this drug without first talking with your healthcare provider. Taking Gabapentin with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse. Do not drive, operate heavy machinery, or do other dangerous activities until you know how Gabapentin affects you. Gabapentin can slow your thinking and motor skills.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking Gabapentin with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine.

How Should Tegretol Be Taken?

The starting dose of Tegretol to treat epilepsy in adults and children over 12 years of age is 200 mg twice daily for tablets and XR tablets, or 1 tsp 4 times daily for suspension (400 mg/day). Usual maintenance dose is 800-1200 mg daily. The starting dose to treat trigeminal neuralgia is 100 mg twice daily for tablets or XR tablets, or ½ tsp 4 times daily for suspension, for a total daily dose of 200 mg. Control of pain is maintained in most patients with 400-800 mg daily. Consult your doctor for pediatric doses.

How Should Neurontin, Gralise, Horizant Be Taken?

Take Gabapentin exactly as prescribed. Your healthcare provider will tell you how much Gabapentin to take.

Do not change your dose of Gabapentin without talking to your healthcare provider.

If you take Gabapentin tablets and break a tablet in half, the unused half of the tablet should be taken at your next scheduled dose. Half tablets not used within 28 days of breaking should be thrown away.

Take Gabapentin capsules with water.

Gabapentin) tablets can be taken with or without food. If you take an antacid containing aluminum and magnesium, such as Maalox®, Mylanta®, Gelusil®, Gaviscon®, or Di-Gel®, you should wait at least 2 hours before taking your next dose of Gbapentin.

If you take too much Gabapentin, call your healthcare provider or your local Poison Control Center right away at 1-800-222-1222.

Reviewed on 4/15/2019

SOURCE:

Novartis. Tegretol Product Information.

https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/tegretol.pdf

DailyMed. Neurontin (gabapentin) Drug Information.

https://dailymed.nlm.nih.gov/dailymed/medguide.cfm?setid=ee9ad9ed-6d9f-4ee1-9d7f-cfad438df388

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