Slideshows Images Quizzes


Last reviewed on RxList: 1/26/2017
Tenoretic Side Effects Center

Last reviewed on RxList 10/20/2015

Tenoretic (atenolol and chlorthalidone) is a combination of a beta-blocker and a thiazide diuretic (water pill) used to treat hypertension (high blood pressure). Tenoretic is available in generic form. Common side effects of Tenoretic include dizziness, spinning sensation, lightheadedness, slow heartbeat, tiredness, nausea, diarrhea, constipation, upset stomach, headache, itching or skin rash, impotence, loss of interest in sex, or trouble having an orgasm.

The initial dose is one Tenoretic 50 tablet once a day. If an optimal response is not achieved, the dosage should be increased to one Tenoretic 100 tablet once a day. Tenoretic may interact with other blood pressure medications, dobutamine, indomethacin, isoproterenol, lithium, diabetes medication, diuretics (water pills), or steroids. Tell your doctor all medications you use. During pregnancy, Tenoretic should be used only when prescribed. It may harm a fetus. Atenolol and chlorthalidone pass into breast milk. Atenolol may have undesirable effects on a nursing infant. Discuss the risks and benefits with your doctor before breast-feeding.

Our Tenoretic (atenolol and chlorthalidone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tenoretic Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • fast, slow, or uneven heartbeats;
  • feeling like you might pass out;
  • feeling short of breath, even with mild exertion;
  • swelling, rapid weight gain;
  • pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin, trouble concentrating;
  • confusion, hallucinations, seizure (convulsions);
  • cold feeling in your hands and feet;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • dry mouth, extreme thirst, drowsiness, restless feeling, nausea, vomiting, increased urination, leg discomfort, muscle pain or weakness, fainting; or
  • memory problems, weakness, loss of appetite, feeling unsteady, shallow breathing or breathing that stops.

Less serious side effects may include:

  • dizziness, spinning sensation;
  • tired feeling;
  • diarrhea, constipation, upset stomach;
  • headache;
  • mild itching or skin rash; or
  • impotence, loss of interest in sex, or trouble having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tenoretic (Atenolol and Chlorthalidone)

Tenoretic Professional Information


TENORETIC (atenolol and chlorthalidone) is usually well tolerated in properly selected patients. Most adverse effects have been mild and transient.The adverse effects observed for TENORETIC (atenolol and chlorthalidone) are essentially the same as those seen with the individual components.


The frequency estimates in the following table were derived from controlled studies in which adverse reactions were either volunteered by the patient (US studies) or elicited, eg, by checklist (foreign studies). The reported frequency of elicited adverse effects was higher for both atenolol and placebo treated patients than when these reactions were volunteered. Where frequency of adverse effects for atenolol and placebo is similar, causal relationship to atenolol is uncertain.

  Volunteered (US Studies) Total-Volunteered and Elicited (Foreign + US Studies)
(n = 164)
(n = 206)
(n = 399)
(n = 407)
Bradycardia 3 0 3 0
Cold Extremities 0 0.5 12 5
Postural Hypotension 2 1 4 5
Leg Pain 0 0.5 3 1
Dizziness 4 1 13 6
Vertigo 2 0.5 2 0.2
Light-Headedness 1 0 3 0.7
Tiredness 0.6 0.5 26 13
Fatigue 3 1 6 5
Lethargy 1 0 3 0.7
Drowsiness 0.6 0 2 0.5
Depression 0.6 0.5 12 9
Dreaming 0 0 3 1
Diarrhea 2 0 3 2
Nausea 4 1 3 1
Wheeziness 0 0 3 3
Dyspnea 0.6 1 6 4

During postmarketing experience, the following have been reported in temporal relationship to the use of the drug: elevated liver enzymes and/or bilirubin, hallucinations, headache, impotence, Peyronie's disease, postural hypotension which may be associated with syncope, psoriasiform rash or exacerbation of psoriasis, psychoses, purpura, reversible alopecia, thrombocytopenia, visual disturbance, sick sinus syndrome, and dry mouth. TENORETIC (atenolol and chlorthalidone) , like other beta blockers, has been associated with the development of antinuclear antibodies (ANA), lupus syndrome, and Raynaud's


Cardiovascular: orthostatic hypotension; Gastrointestinal: anorexia, gastric irritation, vomiting, cramping, constipation, jaundice (intrahepatic cholestatic jaundice), pancreatitis; CNS: vertigo, paresthesia, xanthopsia; Hematologic: leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia; Hypersensitivity: purpura, photosensitivity, rash, urticaria, necrotizing angiitis (vasculitis) (cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis); Miscellaneous: hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness. Clinical trials of TENORETIC (atenolol and chlorthalidone) conducted in the United States (89 patients treated with TENORETIC (atenolol and chlorthalidone) ) revealed no new or unexpected adverse effects.

Potential Adverse Effects

In addition, a variety of adverse effects not observed in clinical trials with atenolol but reported with other beta-adrenergic blocking agents should be considered potential adverse effects of atenolol. Nervous System: Reversible mental depression progressing to catatonia; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, decreased performance on neuropsychometrics; Cardiovascular: Intensification of AV block (see CONTRAINDICATIONS); Gastrointestinal: Mesenteric arterial thrombosis, ischemic colitis; Hematologic: Agranulocytosis; Allergic: Erythematous rash, fevercombined with aching and sore throat, laryngospasm and respiratory distress.


There have been reports of skin rashes and/or dry eyes associated with the use of beta-adrenergic blocking drugs. The reported incidence is small, and, in most cases, the symptoms have cleared when treatment was withdrawn. Discontinuance of the drug should be considered if any such reaction is not otherwise explicable. Patients should be closely monitored following cessation of therapy. (See DOSAGE AND ADMINISTRATION.)

The oculomucocutaneous syndrome associated with the beta blocker practolol has not been reported with atenolol (TENORMIN). Furthermore, a number of patients who had previously demonstrated established practolol reactions were transferred to atenolol (TENORMIN) therapy with subsequent resolution or quiescence of the reaction.

Clinical Laboratory Test Findings

Clinically important changes in standard laboratory parameters were rarely associated with the administration of TENORETIC (atenolol and chlorthalidone) . The changes in laboratory parameters were notprogressive and usually were not associated with clinical manifestations. The most common changes were increases inuric acid and decreases in serum potassium.

Read the entire FDA prescribing information for Tenoretic (Atenolol and Chlorthalidone)

Related Resources for Tenoretic

Read the Tenoretic User Reviews »

© Tenoretic Patient Information is supplied by Cerner Multum, Inc. and Tenoretic Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors