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Tetanus Toxoid Adsorbed

Last reviewed on RxList: 12/25/2016
Tetanus Toxoid Adsorbed Side Effects Center

Last reviewed on RxList 3/17/2016

Tetanus Toxoid Adsorbed vaccine is given to provide protection (immunity) against tetanus (lockjaw) in adults and children 7 years or older. Tetanus Toxoid Adsorbed vaccine is available in generic form. Common side effects of Tetanus Toxoid Adsorbed vaccine include:

  •  mild fever
  • joint pain
  • muscle aches
  • nausea
  • tiredness
  • general ill feeling
  • lightheadedness, or
  • injection site reactions (pain itching swelling tenderness redness or a lump).

Tetanus vaccine is usually first given to infants with 2 other vaccines for diphtheria and whooping cough (pertussis) in a series of 3 injections. This medication is usually used as a "booster" dose after this first series. Follow the vaccination schedule provided by the doctor. Tetanus Toxoid Adsorbed vaccine may interact with steroids, treatment for cancer (chemotherapy, radiation, x-rays), azathioprine, basiliximab, cyclosporine, etanercept, leflunomide, muromonab-CD3, mycophenolate mofetil, sirolimus, or tacrolimus. Tell your doctor all medications and supplements you use. During pregnancy, Tetanus Toxoid Adsorbed vaccine should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Tetanus Toxoid Adsorbed vaccine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Tetanus Toxoid Adsorbed Consumer Information

Your child should not receive a booster vaccine if he or she had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shots caused any side effects.

Becoming infected with diphtheria or tetanus is much more dangerous to your child's health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if your child has any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if the child has a serious side effect such as:

  • extreme drowsiness, fainting;
  • severe headache or vomiting;
  • fussiness, irritability, crying for an hour or longer;
  • confusion, seizure (black-out or convulsions); or
  • high fever.

Less serious side effects include:

  • redness, pain, tenderness, swelling, or a hard lump where the shot was given;
  • mild fever;
  • mild fussiness or crying;
  • joint pain, body aches;
  • mild drowsiness; or
  • mild vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.

Read the entire detailed patient monograph for Tetanus Toxoid Adsorbed (Tetanus Toxoid Adsorbed)

Tetanus Toxoid Adsorbed Professional Information

SIDE EFFECTS

Body System As a Whole

Adverse reactions may be local and include redness, warmth, edema, induration with or without tenderness as well as urticaria, and rash. Malaise, transient fever, pain, hypotension, nausea and arthralgia may develop in some patients after the injection. Arthus-type hypersensitivity reactions, characterized by severe local reactions (generally starting 2 to 8 hours after an injection) may occur, particularly in persons who have received multiple prior boosters.1

Rarely, an anaphylactic reaction (i.e., hives, swelling of the mouth, difficulty breathing, hypotension, or shock) and death have been reported after receiving preparations containing tetanus and diphtheria antigens.

Deaths have been reported in temporal association with the administration of tetanus toxoid containing vaccines. On rare occasion, anaphylaxis has been reported following administration of products containing tetanus toxoid. Upon review, a report by the Institute of Medicine (IOM) concluded the evidence established a causal relationship between tetanus toxoid and anaphylaxis.6

Nervous System

The following neurologic illnesses have been reported as temporally associated with vaccine containing tetanus toxoid: neurological complications13 including cochlear lesion,14 brachial plexus neuropathies,14,15 paralysis of the radial nerve,16 paralysis of the recurrent nerve,14 accommodation paresis, Guillain-Barré syndrome (GBS) and EEG disturbances with encephalopathy. The IOM following review of the reports of neurologic events following vaccination with tetanus toxoid, Td or DT, concluded the evidence favored acceptance of a causal relationship between tetanus toxoid and brachial neuritis and GBS.6,17

EPINEPHRINE INJECTION (1:1000) MUST BE IMMEDIATELY AVAILABLE SHOULD AN ACUTE ANAPHYLACTIC REACTION OCCUR DUE TO ANY COMPONENT OF THE VACCINE.

Reporting of Adverse Events

The National Vaccine Injury Compensation Program, established by the National Childhood Vaccine Injury Act of 1986, requires physicians and other health-care providers who administer vaccines to maintain permanent vaccination records and to report occurrences of certain adverse events to the US Department of Health and Human Services. Reportable events include those listed in the Act for each vaccine and events specified in the package insert as contraindications to further doses of the vaccine.9,10

Reporting by parents or guardians of all adverse events after vaccine administration should be encouraged. Adverse events following immunization with vaccine should be reported by health-care providers to the US Department of Health and Human Services (DHHS) Vaccine Adverse Event Reporting System (VAERS). Reporting forms and information about reporting requirements or completion of the form can be obtained from VAERS through a toll-free number 1-800-822-7967.8,9,10

Health-care providers also should report these events to Director of Scientific and Medical Affairs, Aventis Pasteur Inc., Discovery Drive, Swiftwater, PA 18370 or call 1-800-822-2463.

Read the entire FDA prescribing information for Tetanus Toxoid Adsorbed (Tetanus Toxoid Adsorbed)

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© Tetanus Toxoid Adsorbed Patient Information is supplied by Cerner Multum, Inc. and Tetanus Toxoid Adsorbed Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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