Medical Editor: John P. Cunha, DO, FACOEP
What Is Tetanus Toxoid Adsorbed?
Tetanus Toxoid Adsorbed vaccine is given to provide protection (immunity) against tetanus (lockjaw) in adults and children 7 years or older. Tetanus Toxoid Adsorbed vaccine is available in generic form.
What Are Side Effects of Tetanus Toxoid Adsorbed?
Common side effects of Tetanus Toxoid Adsorbed vaccine include:
- mild fever
- joint pain
- muscle aches
- general ill feeling
- lightheadedness, or
- injection site reactions (pain itching swelling tenderness redness or a lump).
Dosage for Tetanus Toxoid Adsorbed
Tetanus vaccine is usually first given to infants with 2 other vaccines for diphtheria and whooping cough (pertussis) in a series of 3 injections. This medication is usually used as a "booster" dose after this first series. Follow the vaccination schedule provided by the doctor.
What Drugs, Substances, or Supplements Interact with Tetanus Toxoid Adsorbed?
Tetanus Toxoid Adsorbed vaccine may interact with steroids, treatment for cancer (chemotherapy, radiation, x-rays), azathioprine, basiliximab, cyclosporine, etanercept, leflunomide, muromonab-CD3, mycophenolate mofetil, sirolimus, or tacrolimus. Tell your doctor all medications and supplements you use.
Tetanus Toxoid Adsorbed During Pregnancy and Breastfeeding
During pregnancy, Tetanus Toxoid Adsorbed vaccine should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Tetanus Toxoid Adsorbed vaccine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if your child has signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Keep track of all side effects your child has. If the child receives a booster dose, tell the vaccination provider if the previous shot caused any side effects.
Becoming infected with diphtheria or tetanus is much more dangerous to your child's health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is low.
Call your doctor at once if your child has:
- severe drowsiness;
- breathing that stops during sleep; or
- nervous system problems--numbness, pain, tingling, weakness, burning or prickly feeling, vision or hearing problems, trouble breathing.
Your child may feel faint after receiving this vaccine.
Common side effects include:
- fussiness or crying;
- fever; or
- loss of appetite, feeding problems.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.
Read the entire detailed patient monograph for Tetanus Toxoid Adsorbed (Tetanus Toxoid Adsorbed)
Body System As a Whole
Adverse reactions may be local and include redness, warmth, edema, induration with or without tenderness as well as urticaria, and rash. Malaise, transient fever, pain, hypotension, nausea and arthralgia may develop in some patients after the injection. Arthus-type hypersensitivity reactions, characterized by severe local reactions (generally starting 2 to 8 hours after an injection) may occur, particularly in persons who have received multiple prior boosters.1
Rarely, an anaphylactic reaction (i.e., hives, swelling of the mouth, difficulty breathing, hypotension, or shock) and death have been reported after receiving preparations containing tetanus and diphtheria antigens.
Deaths have been reported in temporal association with the administration of tetanus toxoid containing vaccines. On rare occasion, anaphylaxis has been reported following administration of products containing tetanus toxoid. Upon review, a report by the Institute of Medicine (IOM) concluded the evidence established a causal relationship between tetanus toxoid and anaphylaxis.6
The following neurologic illnesses have been reported as temporally associated with vaccine containing tetanus toxoid: neurological complications13 including cochlear lesion,14 brachial plexus neuropathies,14,15 paralysis of the radial nerve,16 paralysis of the recurrent nerve,14 accommodation paresis, Guillain-Barré syndrome (GBS) and EEG disturbances with encephalopathy. The IOM following review of the reports of neurologic events following vaccination with tetanus toxoid, Td or DT, concluded the evidence favored acceptance of a causal relationship between tetanus toxoid and brachial neuritis and GBS.6,17
EPINEPHRINE INJECTION (1:1000) MUST BE IMMEDIATELY AVAILABLE SHOULD AN ACUTE ANAPHYLACTIC REACTION OCCUR DUE TO ANY COMPONENT OF THE VACCINE.
Reporting of Adverse Events
The National Vaccine Injury Compensation Program, established by the National Childhood Vaccine Injury Act of 1986, requires physicians and other health-care providers who administer vaccines to maintain permanent vaccination records and to report occurrences of certain adverse events to the US Department of Health and Human Services. Reportable events include those listed in the Act for each vaccine and events specified in the package insert as contraindications to further doses of the vaccine.9,10
Reporting by parents or guardians of all adverse events after vaccine administration should be encouraged. Adverse events following immunization with vaccine should be reported by health-care providers to the US Department of Health and Human Services (DHHS) Vaccine Adverse Event Reporting System (VAERS). Reporting forms and information about reporting requirements or completion of the form can be obtained from VAERS through a toll-free number 1-800-822-7967.8,9,10
Health-care providers also should report these events to Director of Scientific and Medical Affairs, Aventis Pasteur Inc., Discovery Drive, Swiftwater, PA 18370 or call 1-800-822-2463.
Read the entire FDA prescribing information for Tetanus Toxoid Adsorbed (Tetanus Toxoid Adsorbed)
© Tetanus Toxoid Adsorbed Patient Information is supplied by Cerner Multum, Inc. and Tetanus Toxoid Adsorbed Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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