Theophylline in Dextrose Viaflex Side Effects Center

Last updated on RxList: 2/10/2009
Theophylline in Dextrose Viaflex Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/16/2016

Theophylline in Dextrose (theophylline anhydrous) Injection is a methylxanthine used as an adjunct to inhaled beta-2 selective agonists and systemically administered corticosteroids for the treatment of acute exacerbations of the symptoms and reversible airflow obstruction associated with asthma and other chronic lung diseases, e.g., emphysema and chronic bronchitis. The brand Theophylline in Dextrose is discontinued, but generic versions may be available. Common side effects of Theophylline in Dextrose (theophylline anhydrous) Injection include:

  • nausea
  • vomiting
  • headache
  • insomnia
  • diarrhea
  • irritability
  • restlessness
  • muscle tremors
  • increased urination
  • fever, and
  • injection site reactions (infection, blood clot, or swelling)

Dosage of Theophylline In Dextrose is determined by a physician. Theophylline In Dextrose may interact with a wide variety of drugs, including but not limited to, adenosine, adrenaline-like drugs, allopurinol, aminoglutethimide, antiarrhythmics, anti-seizure drugs, benzodiazepines, beta-blockers, birth control pills, cimetidine, digoxin, disulfiram, fluvoxamine, interferon, isoproterenol, methotrexate, moricizine, pentoxifylline, rifampin, St John's wort, sulfinpyrazone, tacrine, thiabendazole, ticlopidine, verapamil, zileuton, tobacco or marijuana smoking, caffeine, and alcohol. Tell your doctor all medications and supplements you use. During pregnancy, Theophylline In Dextrose should be used only if prescribed. This drug passes into breast milk and may cause irritability or other signs of mild toxicity in nursing infants. Consult your doctor before breastfeeding.

Our Theophylline In Dextrose (theophylline anhydrous) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Asthma is a chronic respiratory disease. See Answer
Theophylline in Dextrose Viaflex Professional Information


Adverse reactions associated with theophylline are generally mild when peak serum theophylline concentrations are < 20 mcg/mL and mainly consist of transient caffeine-like adverse effects such as nausea, vomiting, headache, and insomnia. When serum theophylline concentrations exceed 20 mcg/mL, however, theophylline produces a wide range of adverse reactions including persistent vomiting, cardiac arrhythmias, and intractable seizures which can be lethal (see OVERDOSAGE).

Other adverse reactions that have been reported at serum theophylline concentrations < 20 mcg/mL include diarrhea, irritability, restlessness, fine skeletal muscle tremors, and transient diuresis. In patients with hypoxia secondary to COPD, multifocal atrial tachycardia and flutter have been reported at serum theophylline concentrations ≥ 15 mcg/mL. There have been a few isolated reports of seizures at serum theophylline concentrations < 20 mcg/mL in patients with an underlying neurological disease or in elderly patients. The occurrence of seizures in elderly patients with serum theophylline concentrations < 20 mcg/mL may be secondary to decreased protein binding resulting in a larger proportion of the total serum theophylline concentration in the pharmacologically active unbound form. The clinical characteristics of the seizures reported in patients with serum theophylline concentrations < 20 mcg/mL have generally been milder than seizures associated with excessive serum theophylline concentrations resulting from an overdose (i.e., they have generally been transient, often stopped without anticonvulsant therapy, and did not result in neurological residua).

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures, and save the remainder of the fluid for examination if deemed necessary.

Read the entire FDA prescribing information for Theophylline in Dextrose Viaflex (Theophylline Anhydrous Injection Viaflex)


What Is Asthma? Symptoms, Causes, and Treatments See Slideshow

© Theophylline in Dextrose Viaflex Patient Information is supplied by Cerner Multum, Inc. and Theophylline in Dextrose Viaflex Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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