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Thiotepa

Last reviewed on RxList: 3/16/2020
Thiotepa Side Effects Center

What Is Thiotepa?

Thiotepa injection is a cancer (antineoplastic) medication used in the treatment of cancers of the breast, ovary, bladder, and others.

What Are Side Effects of Thiotepa?

Common side effects of Thiotepa include:

  • fatigue
  • weakness
  • nausea
  • vomiting
  • stomach pain
  • loss of appetite
  • redness or inflammation of the eyes
  • puffy eyelids
  • dizziness
  • headache
  • blurred vision
  • temporary hair loss
  • skin discoloration
  • rash or itching
  • injection site pain, or
  • decreased menstruation/missed menstrual periods in women and decreased sperm production in men.

Dosage for Thiotepa

Dosage of Thiotepa is individualized. Consult your doctor.

What Drugs, Substances, or Supplements Interact with Thiotepa?

Thiotepa may interact with “live” vaccines and other drugs. Tell your doctor all medications and supplements you use and all vaccines you have recently received.

Thiotepa During Pregnancy and Breastfeeding

Thiotepa is not recommended for use during pregnancy. It is harmful to a fetus. Men and women should talk to their doctors about using birth control during treatment with thiotepa. It is unknown if thiotepa passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Thiotepa injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Thiotepa Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • skin lesions;
  • pain or burning when you urinate, blood in your urine;
  • little or no urinating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • signs of infection--fever, flu symptoms, mouth and throat ulcers, rapid heart rate, rapid and shallow breathing, fainting;
  • low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • dizziness, headache, blurred vision;
  • nausea, vomiting, stomach pain, loss of appetite;
  • feeling weak or tired;
  • eye redness;
  • pain or irritation where the injection was given;
  • hair loss; or
  • missed menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Thiotepa (Thiotepa Injection)

Thiotepa Professional Information

SIDE EFFECTS

In addition to its effect on the blood-forming elements (see WARNINGS and PRECAUTIONS sections), thiotepa may cause other adverse reactions.

General: Fatigue, weakness. Febrile reaction and discharge from a subcutaneous lesion may occur as the result of breakdown of tumor tissue.

Hypersensitivity Reactions: Allergic reactions - rash, urticaria, laryngeal edema, asthma, anaphylactic shock, wheezing.

Local Reactions: Contact dermatitis, pain at the injection site.

Gastrointestinal: Nausea, vomiting, abdominal pain, anorexia.

Renal: Dysuria, urinary retention. There have been rare reports of chemical cystitis or hemorrhagic cystitis following intravesical, but not parenteral administration of thiotepa.

Respiratory: Prolonged apnea has been reported when succinylcholine was administered prior to surgery, following combined use of thiotepa and other anticancer agents. It was theorized that this was caused by decrease of pseudocholinesterase activity caused by the anticancer drugs.

Neurologic: Dizziness, headache, blurred vision.

Skin: Dermatitis, alopecia. Skin depigmentation has been reported following topical use.

Special Senses: Conjunctivitis.

Reproductive: Amenorrhea, interference with spermatogenesis.

Read the entire FDA prescribing information for Thiotepa (Thiotepa Injection)

Related Resources for Thiotepa

Related Health

© Thiotepa Patient Information is supplied by Cerner Multum, Inc. and Thiotepa Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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