How Do Thymidylate Synthetase Inhibitors Work?

Reviewed on 11/2/2021

HOW DO THYMIDYLATE SYNTHETASE INHIBITORS WORK?

Thymidylate synthetase inhibitors are a class of drugs used to treat the adenocarcinoma of the colon (large intestine), rectum, breast, pancreas, and stomach.

Thymidylate synthetase inhibitors are folate-based potential anticancer chemotherapy medications and a nucleoside analog that work by inhibiting the enzyme thymidylate synthetase (a critical enzyme for DNA replication and cell growth) that further suppresses DNA synthesis.

Thymidylate synthetase inhibitors are administered via intravenous route.

Thymidylate synthetase inhibitors work in the following ways:

  • They are a potential anticancer chemotherapy medication that work by inhibiting the enzyme thymidylate synthase.
  • This inhibition further prevents the methylation of C5 of deoxyuridine monophosphate, thereby inhibiting the synthesis of deoxythymidine monophosphate.
  • Because of this effect, tumor cells cannot undergo DNA synthesis, thus promoting cell death.

HOW ARE THYMIDYLATE SYNTHETASE INHIBITORS USED?

Thymidylate synthetase inhibitors are used to treat conditions such as:

Adenocarcinoma of:

  • Colon
  • Rectum 
  • Stomach
  • Breast
  • Pancreas

WHAT ARE SIDE EFFECTS OF THYMIDYLATE SYNTHETASE INHIBITORS?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow

WHAT ARE NAMES OF THYMIDYLATE SYNTHETASE INHIBITORS?

Generic and brand names of thymidylate synthetase inhibitors include:

References
https://pubmed.ncbi.nlm.nih.gov/10606255/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244944/

https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/012209s040lbl.pdf

https://www.sciencedirect.com/topics/chemistry/thymidylate-synthase-inhibitor

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