Thyquidity Side Effects Center

Last updated on RxList: 12/11/2020
Thyquidity Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Thyquidity?

Thyquidity (levothyroxine sodium) is levothyroxine sodium (T4) indicated as replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism; and as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

What Are Side Effects of Thyquidity?

Side effects of Thyquidity include:

  • irregular heartbeats (arrhythmias),
  • heart attack,
  • shortness of breath,
  • muscle spasm,
  • headache,
  • nervousness,
  • irritability,
  • insomnia,
  • tremors,
  • muscle weakness,
  • increased appetite,
  • weight loss,
  • diarrhea,
  • heat intolerance,
  • menstrual irregularities, and
  • skin rash

Dosage for Thyquidity

The starting dose of Thyquidity depends on a variety of factors, including age, body weight, cardiovascular status, and concomitant medical conditions (including pregnancy), concomitant medications, co-administered food, and the specific nature of the condition being treated. Peak therapeutic effect may not be attained for 4-6 weeks. Thyquidity should be administered once daily, preferably on an empty stomach, one-half to one hour before breakfast.

Thyquidity In Children

Safety and effectiveness of Thyquidity has been established for the treatment of congenital hypothyroidism and acquired hypothyroidism in pediatric patients down to birth.

What Drugs, Substances, or Supplements Interact with Thyquidity?

Thyquidity may interact with other medicines such as:

  • calcium carbonate,
  • ferrous sulfate,
  • orlistat,
  • bile acid sequestrants,
  • ion exchange resins,
  • sucralfate,
  • antacids,
  • proton pump inhibitors (PPIs),
  • clofibrate,
  • estrogen-containing oral contraceptives,
  • estrogens (oral),
  • heroin/methadone,
  • 5-fluorouracil,
  • mitotane,
  • tamoxifen,
  • androgens/anabolic steroids,
  • asparaginase,
  • glucocorticoids,
  • slow-release nicotinic acid,
  • salicylates,
  • carbamazepine,
  • furosemide,
  • heparin,
  • hydantoins,
  • non-steroidal antiinflammatory drugs (NSAIDs)
  • fenamates,
  • phenobarbital,
  • rifampin,
  • beta-adrenergic antagonists,
  • amiodarone,
  • antidiabetic agents or insulin,
  • oral anticoagulants,
  • digitalis glycosides,
  • antidepressants,
  • ketamine,
  • sympathomimetics,
  • tyrosine-kinase inhibitors,
  • soybean products,
  • cottonseed meal,
  • walnuts,
  • dietary fiber, and
  • grapefruit juice

Thyquidity During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Thyquidity; pregnancy may require the use of higher doses of Thyquidity. Thyquidity passes into breast milk. No adverse effects on breastfed infants have been reported and there is no information on the effects of Thyquidity on milk production. Consult your doctor before breastfeeding.

Additional Information

Our Thyquidity (levothyroxine sodium) Oral Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Where is the thyroid gland located? See Answer
Thyquidity Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or irregular heartbeats;
  • chest pain, pain spreading to your jaw or shoulder;
  • shortness of breath;
  • fever, hot flashes, sweating;
  • tremors, or if you feel unusually cold;
  • weakness, tiredness, sleep problems (insomnia);
  • memory problems, feeling depressed or irritable;
  • headache, leg cramps, muscle aches;
  • feeling nervous or irritable;
  • dryness of your skin or hair, hair loss;
  • irregular menstrual periods; or
  • vomiting, diarrhea, appetite changes, weight changes.

Certain side effects may be more likely in older adults.

Common side effects may include:

  • chest pain, irregular heartbeats;
  • shortness of breath;
  • headache, leg cramps, muscle pain or weakness;
  • tremors, feeling nervous or irritable, trouble sleeping;
  • increased appetite;
  • feeling hot;
  • weight loss;
  • changes in your menstrual periods;
  • diarrhea; or
  • skin rash, partial hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Hyperthyroidism Symptoms and Treatment See Slideshow
Thyquidity Professional Information


Adverse reactions associated with THYQUIDITY therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see WARNINGS AND PRECAUTIONS, OVERDOSE]. They include the following:

  • General: fatigue, increased appetite, weight loss, heat intolerance, fever, excessive sweating
  • Central nervous system: headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, insomnia
  • Musculoskeletal: tremors, muscle weakness, muscle spasm
  • Cardiovascular: palpitations, tachycardia, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrest
  • Respiratory: dyspnea
  • Gastrointestinal: diarrhea, vomiting, abdominal cramps, elevations in liver function tests
  • Dermatologic: hair loss, flushing, rash
  • Endocrine: decreased bone mineral density
  • Reproductive: menstrual irregularities, impaired fertility

Seizures have been reported rarely with the institution of levothyroxine therapy.

Adverse Reactions In Children

Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in children receiving levothyroxine therapy. Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height.

Hypersensitivity Reactions

Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. These include urticaria, pruritus, skin rash, flushing, angioedema, various gastrointestinal symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness, and wheezing. Hypersensitivity to levothyroxine itself is not known to occur.

Read the entire FDA prescribing information for Thyquidity (Levothyroxine Sodium Oral Solution)

© Thyquidity Patient Information is supplied by Cerner Multum, Inc. and Thyquidity Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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