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Thyroid Nodules

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Thyroid nodules facts

  • Thyroid nodules are among the most common endocrine complaints in the United States.
  • The majority of thyroid nodules are benign.
  • Thyroid nodules are more likely to be cancerous at the extremes of age and in males.
  • The most malignant thyroid cancers are seen at the extremes of age.
  • Most thyroid cancers are found between ages 20 to 50.
  • Exposure to radiation also increases the probability that a nodule is cancerous.
  • A solitary nodule is more likely to be cancerous than multiple nodules.
  • A nodule arising in a thyroid with normal function is more likely to be cancerous than those arising in a hyperfunctioning gland.
  • Diagnosis of thyroid cancer is aided by ultrasonography and radionuclide scanning, but is best made by fine needle aspiration (FNA). Cautions with FNA relate to possible incorrect diagnosis or non-diagnostic interpretations from the aspirate(s).
  • Hyperfunctioning nodules require treatment aimed at controlling signs and symptoms of hyperthyroidism.

Cancerous and nodules highly suspicious for cancer should be removed. The rest should be followed closely and re-assessed frequently.

Introduction to thyroid nodules

The term "thyroid nodule" refers to any abnormal growth that forms a lump in the thyroid gland.

The thyroid gland is located low in the front of the neck, below the Adam's apple. The gland is shaped like a butterfly and wraps around the windpipe or trachea. The two wings or lobes on either side of the windpipe are joined together by a bridge of tissue, called the isthmus, which crosses over the front of the windpipe.

A thyroid nodule can occur in any part of the gland. Some nodules can be felt quite easily. Others can be hidden deep in the thyroid tissue or located very low in the gland, where they are difficult to feel.

What is the prevalence of thyroid nodules and cancer?

Modern imaging techniques - such as ultrasound (US), computerized tomography (CT), and magnetic resonance imaging (MRI) - have revealed more thyroid nodules incidentally This means that nodules are being found during studies that were done for reasons other than examination of the thyroid per se. Up to 4% to 8% of adult women and 1% to 2% of adult men have thyroid nodules detectable by physical examination. Closer to 30% of adult women have nodules detectable by ultrasound. In fact, diagnosis of a thyroid nodule is the most common endocrine problem in the United States.

Although the majority of thyroid nodules are benign (not cancerous), about 10% of nodules do contain cancer. Therefore, the primary purpose for evaluating a thyroid nodule is to determine whether cancer is present.

Thyroid Gland
Picture of the thyroid gland

Medically Reviewed by a Doctor on 8/11/2016


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