Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 3/21/2022
Thyrolar Side Effects Center

What Is Thyrolar?

Thyrolar Tablets (liotrix) is a synthetic thyroid hormone used to treat hypothyroidism (low thyroid hormone), and to treat or prevent goiter (enlarged thyroid gland). Thyrolar is also given as part of medical testing for thyroid disorders.

What Are Side Effects of Thyrolar?

Common side effects of Thyrolar include temporary hair loss (especially in children) during the first few months of starting this drug. Other side effects of Thyrolar may include diarrhea, bone pain, headache, mental/mood changes (e.g., nervousness, mood swings, depression, anxiety), shaking (tremor), sensitivity to heat, increased sweating, tiredness, nausea, weakness, weight gain, dry or itchy skin, or joint or muscle pain.

Dosage for Thyrolar

The usual starting dose is one tablet of Thyrolar ½ with increments of one tablet of Thyrolar ΒΌ every 2 to 3 weeks.

What Drugs, Substances, or Supplements Interact with Thyrolar?

Thyrolar may interact with birth control pills or hormone replacement therapy, blood thinners, digoxin, epinephrine or norepinephrine, insulin or oral diabetes medication, medications that contain iodine, antidepressants, salicylates such as aspirin or Pepto-Bismol and others, or steroids. Tell your doctor all medications and supplements you use.

Thyrolar During Pregnancy or Breastfeeding

Current information shows that Thyrolar may be used during pregnancy. Tell your doctor if you are pregnant or if you become pregnant because your dose may need to be adjusted. Small amounts of this medication pass into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Thyrolar Tablets (liotrix) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Hyperthyroidism Symptoms and Treatment See Slideshow
Thyrolar Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using liotrix and call your doctor if you have symptoms of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual.

Also call your doctor at once if you have:

  • vomiting, diarrhea;
  • fever, swollen glands, itching, joint pain, or not feeling well;
  • flushing (sudden warmth, redness, or tingly feeling);
  • chest pressure spreading to your jaw or shoulder;
  • shortness of breath;
  • weak or shallow breathing;
  • headache, tremors, trouble sleeping, feeling nervous or irritable;
  • changes in weight or appetite;
  • changes in your menstrual periods;
  • severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes;
  • thinking problems, trouble concentrating, poor academic performance; or
  • (in a child or teenager) pain, stiffness, and trouble moving the legs.

Common side effects may include:

  • headache, tiredness, mood changes;
  • tremors, feeling anxious;
  • fast heart rate, increased blood pressure;
  • muscle weakness;
  • increased appetite;
  • stomach cramps;
  • hair loss; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Thyrolar (Liotrix)


Where is the thyroid gland located? See Answer
Thyrolar Professional Information


During postmarketing surveillance, the following events have been observed to have occured in patients administered Thyrolar (liotrix) : fatigue, sluggishness, increase in weight, alopecia, palpitations, dry skin, urticaria, headache, hyperhidrosis, pruritus, asthenia, increased blood pressure, arthralgia, myalgia, tremor, hypothyroidism, increase in TSH, decrease in TSH, nausea, chest pain, hypersensitivity, keratoconjunctivitis sicca, increased heart rate, irregular heart rate, anxiety, depression, and insomnia.

Adverse reactions other than those indicative of hyperthyroidism because of therapeutic overdosage, either initially or during the maintenance period, are rare (See OVERDOSAGE).

Read the entire FDA prescribing information for Thyrolar (Liotrix)

© Thyrolar Patient Information is supplied by Cerner Multum, Inc. and Thyrolar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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