Ticlopidine (Discontinued)

Reviewed on 8/4/2022

What Is Ticlopidine and How Does It Work?

Ticlopidine is a prescription medication used for the treatment of stroke and prevention of thrombosis after coronary stent placement.

  • Ticlopidine is available under the following different brand names: Ticlid

What Are Side Effects Associated with Using Ticlopidine?

Common side effects of Ticlopidine include:

  • diarrhea,
  • stomach upset or pain,
  • nausea,
  • vomiting,
  • dizziness,
  • ringing in the ears, or
  • itching

Serious side effects of Ticlopidine include:

  • hives,
  • difficulty breathing,
  • swelling of the face, lips, tongue, or throat,
  • any bleeding that will not stop;
  • severe or ongoing diarrhea;
  • pink or brown urine;
  • low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding, feeling light-headed;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
  • signs of a serious blood-clotting problem--pale skin, purple spots under the skin or on the mouth, problems with speech, weakness, seizures (convulsions), dark urine, jaundice.

Rare side effects of Ticlopidine include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors;
  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheartedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

What Are Dosages of Ticlopidine?

Adult dosage

  • Discontinued; no longer available in the United States

Stroke

Adult and geriatric dosage

  • 250 mg orally every 12 hours with food

Coronary Artery Stent Thrombosis, Prevention

Adult and geriatric dosage

  • 250 mg orally every 12 hours with aspirin for 30 days OR
  • ACCP: Load 500 mg, THEN 250 mg every 12 hours for at least 10-14 days following successful stent placement

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Other Drugs Interact with Ticlopidine?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Ticlopidine has severe interactions with the following drugs:
    • abrocitinib
    • eliglustat
    • mavacamten
  • Ticlopidine has serious interactions with at least 26 other drugs.
  • Ticlopidine has moderate interactions with at least 73 other drugs.
  • Ticlopidine has minor interactions with at least 20 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Ticlopidine?

Contraindications

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Ticlopidine?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Ticlopidine?”

Cautions

  • Due to the risk of adverse hematologic events, stroke prevention used only in ASA-intolerant patients
  • Patients with lesions that have a propensity to bleed
  • Discontinue 10-14 days before elective major surgery in patients with bleeding diathesis
  • Increases serum cholesterol & triglyceride concentrations
  • Long-term use with concurrent aspirin is not recommended

Pregnancy and Lactation

  • May be acceptable during pregnancy
  • Lactation
    • Not known whether excreted in breast milk, discontinue the drug or do not nurse
References
https://reference.medscape.com/drug/ticlid-ticlopidine-342184#6

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