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Last reviewed on RxList: 12/15/2016
Timentin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/8/2016

Timentin (ticarcillin disodium and clavulanate potassium) is a combination of a penicillin antibiotic and a form of clavulanic acid, similar to penicillin, used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, and skin infections. Common side effects of Timentin include:

  • mild diarrhea
  • gas
  • stomach pain
  • nausea
  • vomiting
  • joint or muscle pain
  • headache
  • skin rash or itching
  • injection site reactions (pain, swelling, or burning)
  • vaginal yeast infection (itching or discharge)

Tell your doctor if you experience serious side effects of Timentin including:

  • watery or bloody diarrhea
  • blood in your urine
  • feeling an urgent need to urinate
  • painful or difficult urination
  • easy bruising or bleeding
  • unusual weakness
  • dry mouth
  • increased thirst
  • confusion
  • increased urination
  • muscle pain or weakness
  • fast heart rate
  • lightheadedness
  • fainting
  • fever
  • chills
  • body aches
  • flu symptoms: fever, sore throat, and headache with a severe blistering, peeling, and red skin rash
  • chest pain
  • seizures (convulsions)

The recommended adult dosage for systemic and urinary tract infections is 3.1 grams of Timentin given every 4 to 6 hours. Pediatric dose is based on the child's weight. Other drugs may interact with Timentin. Tell your doctor all prescription and over-the-counter medications you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Timentin. Timentin can make birth control pills less effective. Use a second non-hormone method of birth control (such as a condom, diaphragm, spermicide) while using this drug. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Timentin (ticarcillin disodium and clavulanate potassium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Timentin Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • blood in your urine, feeling an urgent need to urinate, painful or difficult urination;
  • easy bruising or bleeding, unusual weakness;
  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;
  • fever, chills, body aches, flu symptoms;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • chest pain; or
  • seizure (convulsions).

Less serious side effects may include:

  • mild diarrhea, gas, stomach pain;
  • nausea or vomiting;
  • joint or muscle pain;
  • headache;
  • skin rash or itching;
  • pain, swelling, or burning where the injection was given; or
  • vaginal yeast infection (itching or discharge).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Timentin (Ticarcillin and Clavulanate)

Timentin Professional Information


As with other penicillins, the following adverse reactions may occur:

Hypersensitivity Reactions

Skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, and anaphylactic reactions.

Central Nervous System

Headache, giddiness, neuromuscular hyperirritability, or convulsive seizures.

Gastrointestinal Disturbances

Disturbances of taste and smell, stomatitis, flatulence, nausea, vomiting and diarrhea, epigastric pain, and pseudomembranous colitis have been reported. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. (See WARNINGS.)

Hemic and Lymphatic Systems

Thrombocytopenia, leukopenia, neutropenia, eosinophilia, reduction of hemoglobin or hematocrit, and prolongation of prothrombin time and bleeding time.

Abnormalities of Hepatic Function Tests

Elevation of serum aspartate aminotransferase (SGOT), serum alanine aminotransferase (SGPT), serum alkaline phosphatase, serum LDH, serum bilirubin. There have been reports of transient hepatitis and cholestatic jaundice-as with some other penicillins and some cephalosporins.

Renal and Urinary Effects

Hemorrhagic cystitis, elevation of serum creatinine and/or BUN, hypernatremia, reduction in serum potassium, and uric acid.

Local Reactions

Pain, burning, swelling, and induration at the injection site and thrombophlebitis with intravenous administration.

Available safety data for pediatric patients treated with TIMENTIN demonstrate a similar adverse event profile to that observed in adult patients.

Drug Abuse And Dependence

Neither abuse of nor dependence on TIMENTIN has been reported.

Read the entire FDA prescribing information for Timentin (Ticarcillin and Clavulanate)

Related Resources for Timentin

© Timentin Patient Information is supplied by Cerner Multum, Inc. and Timentin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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