Timoptic-XE

Last updated on RxList: 4/25/2019
Timoptic-XE Side Effects Center

Last reviewed on RxList 4/25/2019

Timoptic-XE (timolol maleate ophthalmic solution) is a beta-blocker used to treat open-angle glaucoma and other causes of high pressure inside the eye. Timoptic-XE is available in generic form. Common side effects of Timoptic-XE include temporary blurred vision, double vision, drooping eyelid, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, headache, weakness, dizziness, drowsiness, numbness/tingling/cold feeling in your hands or feet, ringing in your ears, dry mouth, nausea, diarrhea, loss of appetite, upset stomach, skin rash or worsening psoriasis, sleep problems (insomnia), cough, or stuffy nose.

The dose of Timoptic-XE is one drop (either 0.25% or 0.5%) in the affected eye(s) once a day. Timoptic-XE may interact with clonidine, quinidine, reserpine, digitalis, acetazolamide, dichlorphenamide, methazolamide, oral timolol, other beta-blockers, calcium channel blockers, or antidepressants. Tell your doctor all medications and supplements you use. Timoptic-XE should be used only when prescribed during pregnancy. This drug passes into breast milk. Consult your doctor before breastfeeding.

Our Timoptic-XE (timolol maleate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Timoptic-XE Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when timolol is used in the eyes, side effects can occur if the medicine is absorbed into your bloodstream. Call your doctor right away if you have:

  • wheezing, chest pain, trouble breathing, slow heartbeats;
  • a light-headed feeling, like you might pass out;
  • muscle weakness;
  • depressed mood, confusion, hallucinations, unusual thoughts or behavior; or
  • numbness or cold feeling in your hands and feet.

Also call your doctor if you have:

  • severe stinging or burning after using the eye drops:
  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection); or
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights.

Common side effects may include:

  • burning or stinging in your eye;
  • dry eyes, itching;
  • feeling like something is in your eye;
  • red or puffy eyelids; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Timoptic-XE (Timolol Maleate Ophthalmic Gel Forming Solution)

SLIDESHOW

Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow
Timoptic-XE Professional Information

SIDE EFFECTS

In clinical trials, transient blurred vision upon instillation of the drop was reported in approximately one in three patients (lasting from 30 seconds to 5 minutes). Less than 1% of patients discontinued from the studies due to blurred vision. The frequency of patients reporting burning and stinging upon instillation was comparable between TIMOPTIC-XE and TIMOPTIC (approximately one in eight patients).

Adverse experiences reported in 1-5% of patients were:

Ocular: Pain, conjunctivitis, discharge (e.g., crusting), foreign body sensation, itching and tearing;

Systemic: Headache, dizziness, and upper respiratory infections.

The following additional adverse experiences have been reported with the ocular administration of this or other timolol maleate formulations:

Body As A Whole

Asthenia/fatigue, and chest pain.

Cardiovascular

Bradycardia, arrhythmia, hypotension, hypertension, syncope, heart block, cerebral vascular accident, cerebral ischemia, cardiac failure, worsening of angina pectoris, palpitation, cardiac arrest, pulmonary edema, edema, claudication, Raynaud's phenomenon, and cold hands and feet.

Digestive

Nausea, diarrhea, dyspepsia, anorexia, and dry mouth.

Immunologic

Systemic lupus erythematosus.

Nervous System/Psychiatric

Increase in signs and symptoms of myasthenia gravis, paresthesia, somnolence, insomnia, nightmares, behavioral changes and psychic disturbances including depression, confusion, hallucinations, anxiety, disorientation, nervousness, and memory loss.

Skin

Alopecia and psoriasiform rash or exacerbation of psoriasis.

Hypersensitivity

Signs and symptoms of systemic allergic reactions including anaphylaxis, angioedema, urticaria, localized and generalized rash.

Respiratory

Bronchospasm (predominantly in patients with preexisting bronchospastic disease), respiratory failure, dyspnea, nasal congestion, cough and upper respiratory infections.

Endocrine

Masked symptoms of hypoglycemia in diabetic patients [see WARNINGS].

Special Senses

Signs and symptoms of ocular irritation including blepharitis, keratitis, and dry eyes; ptosis; decreased corneal sensitivity; cystoid macular edema; visual disturbances including refractive changes and diplopia; pseudopemphigoid; choroidal detachment following filtration surgery [see PRECAUTIONS, General]; and tinnitus.

Urogenital

Retroperitoneal fibrosis, decreased libido, impotence, and Peyronie's disease. The following additional adverse effects have been reported in clinical experience with ORAL timolol maleate or other ORAL beta-blocking agents and may be considered potential effects of ophthalmic timolol maleate: Allergic: Erythematous rash, fever combined with aching and sore throat, laryngospasm with respiratory distress; Body as a Whole: Extremity pain, decreased exercise tolerance, weight loss; Cardiovascular: Worsening of arterial insufficiency, vasodilatation; Digestive: Gastrointestinal pain, hepatomegaly, vomiting, mesenteric arterial thrombosis, ischemic colitis; Hematologic: Nonthrombocytopenic purpura, thrombocytopenic purpura, agranulocytosis; Endocrine: Hyperglycemia, hypoglycemia; Skin: Pruritus, skin irritation, increased pigmentation, sweating; Musculoskeletal: Arthralgia; Nervous System/Psychiatric: Vertigo, local weakness, diminished concentration, reversible mental depression progressing to catatonia, an acute reversible syndrome characterized by disorientation for time and place, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics; Respiratory: Rales, bronchial obstruction; Urogenital: Urination difficulties.

Read the entire FDA prescribing information for Timoptic-XE (Timolol Maleate Ophthalmic Gel Forming Solution)

© Timoptic-XE Patient Information is supplied by Cerner Multum, Inc. and Timoptic-XE Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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