Tobramycin Injection Side Effects Center

Last updated on RxList: 5/27/2021
Tobramycin Injection Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Tobramycin Injection?

Tobramycin for Injection is an antibiotic used to treat serious bacterial infections. Tobramycin for Injection is available in generic form.

What Are Side Effects of Tobramycin Injection?

Common side effects of Tobramycin for Injection include dizziness, spinning sensation (vertigo), ringing in the ears, kidney problems, anemia, fever, rash, itching, nausea, vomiting, stomach upset, loss of appetite, diarrhea, headache, lethargy, injection site reactions (pain, irritation, or redness), and confusion.

Dosage for Tobramycin Injection

The dose of Tobramycin for Injection is based on the patient's body weight.

What Drugs, Substances, or Supplements Interact with Tobramycin Injection?

Tobramycin for Injection may interact with other drugs. Tell your doctor all medications and supplements you use.

Tobramycin Injection During Pregnancy or Breastfeeding

Tobramycin for Injection should not be used during pregnancy. It may harm a fetus. Consult your doctor before breastfeeding.

Additional Information

Our Tobramycin for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Fungal Skin Infections: Types, Symptoms, and Treatments See Slideshow
Tobramycin Injection Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tobramycin can damage nerves and may cause hearing loss that may be permanent. Tell your doctor right away if you have:

  • numbness, tingling, muscle stiffness or uncontrolled twitching;
  • dizziness, spinning sensation, seizure (convulsions); or
  • hearing loss, or a ringing or roaring sound in your ears (even after you have stopped using tobramycin injection).

Call your doctor at once if you have:

  • swelling, rapid weight gain, little or no urinating;
  • confusion, loss of appetite, vomiting, pain in your side or lower back;
  • fever; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • headache;
  • lack of energy;
  • mild rash or itching;
  • nausea, vomiting, diarrhea; or
  • pain where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tobramycin Injection (Tobramycin Injection)


Bowel regularity means a bowel movement every day. See Answer
Tobramycin Injection Professional Information


Adverse reactions have occurred with steroid/anti-infective combination drugs which can be attributed to the steroid component, the anti-infective component, or the combination. Exact incidence figures are not available.

The most frequent adverse reactions to topical ocular tobramycin [TOBREX (tobramycin ophthalmic solution) 0.3%] are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than 4% of patients.

The reactions due to the steroid component are: elevation of IOP with possible development of glaucoma, and infrequent optic nerve damage; posterior subcapsular cataract formation; and delayed wound healing.

Secondary Infection

The development of secondary infection has occurred after use of combinations containing steroids and antimicrobials. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term applications of steroids. The possibility of fungal invasion must be considered in any persistent corneal ulceration where steroid treatment has been used. Secondary bacterial ocular infection following suppression of host responses also occurs.

Postmarketing Experience

Additional adverse reactions identified from postmarketing use include anaphylactic reaction, erythema multiforme.

The following additional adverse reactions have been reported with the individual components listed below:


Cushing's syndrome and adrenal suppression may occur after use of dexamethasone in excess of the listed dosing instructions in predisposed patients, including children and patients treated with CYP3A4 inhibitors.


Neurotoxicity, ototoxicity, and nephrotoxicity have occurred in patients receiving systemic aminoglycoside therapy. Aminoglycosides may aggravate muscle weakness in patients with known or suspected neuromuscular disorders, such as myasthenia gravis or Parkinson's disease, because of their potential effect on neuromuscular function.


No Information provided

Read the entire FDA prescribing information for Tobramycin Injection (Tobramycin Injection)

© Tobramycin Injection Patient Information is supplied by Cerner Multum, Inc. and Tobramycin Injection Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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