Last updated on RxList: 10/15/2019
Tolinase Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/15/2019

Tolinase (tolazamide) is an oral diabetes medicine used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with Tolinase if needed. The brand name Tolinase is discontinued but generic versions may be available. Common side effects of Tolinase (tolazamide) include:

The most common side effect of Tolinase (tolazamide) is low blood sugar (hypoglycemia); symptoms include headache hunger weakness sweating tremor irritability trouble concentrating rapid breathing fast heartbeat fainting or seizure (severe hypoglycemia can be fatal).

The usual starting dose of Tolinase Tablets for the mild to moderately severe Type II diabetic patient is 100-250 mg daily administered with breakfast or the first main meal. Tolinase may interact with alcohol. High blood sugar (hyperglycemia) may result if you take Tolinase with isoniazid, diuretics, steroids, heart or blood pressure medications, niacin, phenothiazines, thyroid medicines, birth control pills and other hormones, seizure medicines, diet pills or medicines to treat asthma, colds or allergies. Low blood sugar (hypoglycemia) may result if you take Tolinase with exenatide, probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, blood thinners, heart or blood pressure medications, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or other oral diabetes medications. Tell your doctor all medications and supplements you use. Tolinase should be used only when prescribed during pregnancy. It is not recommended for use for at least 2 weeks before delivery because it may cause low blood sugar in the newborn. Your doctor may substitute insulin for this drug during your pregnancy. It is unknown if this drug passes into breast milk. Similar drugs pass into breast milk. Consult your doctor before breastfeeding.

Our Tolinase (tolazamide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


______________ is another term for type 2 diabetes. See Answer
Tolinase Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • dark urine, jaundice (yellowing of the skin or eyes);
  • severe skin rash, redness, or itching;
  • pale skin, easy bruising or bleeding;
  • fever, chills, sore throat, mouth sores; or
  • low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Older adults may be more likely to have low blood sugar while taking this medicine.

Common side effects may include:

  • nausea;
  • heartburn; or
  • full feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tolinase (Tolazamide Tablets)


Type 2 Diabetes: Signs, Symptoms, Treatments See Slideshow
Tolinase Professional Information


TOLINASE (tolazamide) Tablets have generally been well tolerated. In clinical studies in which more than 1,784 diabetic patients were specifically evaluated for incidence of side effects, only 2.1% were discontinued from therapy because of side effects.

Hypoglycemia: See PRECAUTIONS and OVERDOSAGE sections.

Gastrointestinal Reactions: Cholestatic jaundice may occur rarely; TOLINASE (tolazamide) Tablets should be discontinued if this occurs. Gastrointestinal disturbances, eg, nausea, epigastric fullness, and heartburn, are the most common reactions and occurred in 1% of patients treated during clinical trials. They tend to be dose-related and may disappear when dosage is reduced.

Dermatologic Reactions: Allergic skin reactions, eg, pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, occurred in 0.4% of patients treated during clinical trials. These may be transient and may disappear despite continued use of TOLINASE (tolazamide) ; if skin reactions persist, the drug should be discontinued.

Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.

Hematologic Reactions: Leukopenia, agranulocy-tosis, thrombocytopenia, hemolytic anemia, aplas-tic anemia, and pancytopenia have been reported with sulfonylureas.

Metabolic Reactions: Hepatic porphyria and disul-firam-like reactions have been reported with sul-fonylureas; however, disulfiram-like reactions with TOLINASE (tolazamide) have been reported very rarely.

Cases of hyponatremia have been reported with tolazamide and all other sulfonylureas, most often in patients who are on other medications or have medical conditions known to cause hyponatremia or increase release of antidiuretic hormone. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported with certain other sul-fonylureas, and it has been suggested that these sul-fonylureas may augment the peripheral (antidiuretic) action of ADH and/or increase release of ADH.

Miscellaneous: Weakness, fatigue, dizziness, vertigo, malaise and headache were reported infrequently in patients treated during clinical trials. The relationship to therapy with TOLINASE (tolazamide) is difficult to assess.

Read the entire FDA prescribing information for Tolinase (Tolazamide Tablets)

© Tolinase Patient Information is supplied by Cerner Multum, Inc. and Tolinase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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