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Topamax vs. Keppra

  • Medical and Pharmacy Editor: John P. Cunha, DO, FACOEP
    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, FACOEP

    John P. Cunha, DO, is a U.S. board-certified Emergency Medicine Physician. Dr. Cunha's educational background includes a BS in Biology from Rutgers, the State University of New Jersey, and a DO from the Kansas City University of Medicine and Biosciences in Kansas City, MO. He completed residency training in Emergency Medicine at Newark Beth Israel Medical Center in Newark, New Jersey.

Are Topamax and Keppra the Same Thing?

Topamax (topiramate) and Keppra (levetiracetam) are anticonvulsants used to prevent epileptic seizures.

Topamax is also used to prevent migraine headaches.

What Are Possible Side Effects of Topamax?

Common side effects of Topamax include:

What Are Possible Side Effects of Keppra?

Common side effects of Keppra include:

Side effects of Keppra in children include

  • sleepiness,
  • accidental injury,
  • hostility, nervousness, and
  • weakness.

Anti-epileptic drugs (AEDs), including Keppra, increase the risk of suicidal thoughts or behavior. Patients should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual mood or behavior changes.

What Is Topamax?

Topamax (topiramate) is an anticonvulsant prescribed for preventing epileptic seizures and migraine headaches. Topamax is available as a generic drug.

What Is Keppra?

Keppra (levetiracetam) is an anti-epileptic drug (AED) (antoconvulsant) often used in conjunction with other drugs to treat types of seizures in people with epilepsy.

What Drugs Interact With Topamax?

Topamax may interact with other medicines that can make you sleepy (cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety), other seizure medications, lithium, hydrochlorothiazide, metformin, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, bladder or urinary medications, or glaucoma medications.

What Drugs Interact With Keppra?

Keppra may interact with other seizure medications.

Keppra may also interact with alcohol, oral contraceptives, digoxin, warfarin, and probenecid.

How Should Topamax Be Taken?

Topamax usual adult dose is 200mg twice a day. Drug interactions include acetazolamide (Diamox), methazolamide (Neptazane), dichlorphenamide (Daranide), carbamazepine (Tegretol) and phenytoin (Dilantin) and oral contraceptives. There are no adequate studies of Topamax in pregnant women and it is not known if Topamax is secreted in human breast milk. Use during pregnancy is not recommended unless the potential benefit outweighs the potential unknown risk to the fetus. Topamax passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

How Should Keppra Be Taken?

Keppra (levetiracetam) is available in pills in the following dosages and colors: 250 mg (blue), 500 mg (yellow), 750 mg (orange), and 1,000 mg (white). Keppra (levetiracetam) is also available as a clear, colorless grape-flavored liquid at a concentration of 100 mg/mL.

Reviewed on 4/17/2019

References:
RxList. Topamax Medication Guide.
https://www.rxlist.com/topamax-drug.htm
RxList. Keppra Medication Guide.
https://www.rxlist.com/keppra-drug.htm#medguide

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