Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 10/29/2021
Topicort Side Effects Center

What Is Topicort?

Topicort (desoximetasone) is a topical (for the skin) steroid used treat to the inflammation and itching caused by a number of skin conditions such as allergic reactions, eczema, and psoriasis. Topicort is available in generic form.

What Are Side Effects of Topicort?

Common side effects of Topicort include:

  • burning,
  • itching,
  • irritation,
  • peeling, or dryness when this medication is first applied to the skin.

Other side effects of Topicort include:

  • thinning or softening of your skin,
  • skin rash or irritation around your mouth,
  • swollen hair follicles,
  • changes in color of treated skin,
  • stretch marks,
  • blisters,
  • pimples, or
  • crusting of treated skin.

Dosage for Topicort

Topicort comes in a 0.05% dose cream, gel, and ointment, applied in a thin film to the affected skin areas twice daily.

What Drugs, Substances, or Supplements Interact with Topicort?

It is not likely that other drugs you take orally or inject will have an effect on topically applied Topicort. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Topicort During Pregnancy and Breastfeeding

Topicort should be used only when prescribed during pregnancy. It is not known whether this drug, when applied to the skin, passes into breast milk. Other medications in this class, when taken by mouth, pass into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Topicort Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Topicort Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • rash, itching, or irritation around your mouth;
  • burning, irritation, itching, or dryness of treated skin;
  • redness or crusting around your hair follicles;
  • increased hair growth;
  • blisters, pimples, or crusting of treated skin;
  • changes in color of treated skin;
  • white or "pruned" appearance of the skin; or
  • stretch marks.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Topicort (Desoximetasone)


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Topicort Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In randomized, multicenter, prospective vehicle-controlled clinical trials, subjects with moderate to severe plaque psoriasis of the body applied Topicort Topical Spray or vehicle spray twice daily for 4 weeks. A total of 149 subjects applied Topicort Topical Spray.

Adverse reactions that occurred in ≥ 1% of subjects treated with Topicort Topical Spray are presented in Table 1.

Table 1: Number (%) of Subjects with Adverse Reactions Occurring in ≥ 1%

Topicort Topical Spray, 0.25% b.i.d
(N = 149)
Vehicle spray b.i.d.
(N = 135)
Number of Subjects with Adverse Reactions 13 (8.7%) 18 (13.3%)
Application site dryness 4 (2.7%) 7 (5.2%)
Application site irritation 4 (2.7%) 5 (3.7%)
Application site pruritus 3 (2.0%) 5 (3.7%)

Another less common adverse reaction (<1% but >0.1%) was folliculitis.

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing reports for local adverse reactions to topical corticosteroids included atrophy, striae, telangiectasias, itching, dryness, hypopigmentation, perioral dermatitis, secondary infection, and miliaria.

Ophthalmic adverse reactions of cataracts, glaucoma, and increased intraocular pressure have been reported during use of topical corticosteroids.


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Read the entire FDA prescribing information for Topicort (Desoximetasone)

© Topicort Patient Information is supplied by Cerner Multum, Inc. and Topicort Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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