Tradjenta vs. Glucotrol

Are Tradjenta and Glucotrol the Same Thing?

Tradjenta (linagliptin) and Glucotrol (glipizide) are oral diabetes medicines used as adjuncts to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Side effects of Tradjenta and Glucotrol that are similar include weight gain and headache.

Side effects of Tradjenta that are different from Glucotrol include stuffy nose, runny nose, sore throat, cough, muscle or joint pain, back pain, or low blood sugar.

Side effects of Glucotrol that are different from Tradjenta include diarrhea, constipation, nausea, vomiting, upset stomach, loss of appetite, skin changes (skin rash, hives, redness, itching, and blisters), gas, drowsiness, and dizziness.

Both Tradjenta and Glucotrol may interact with nonsteroidal anti-inflammatory drugs (NSAIDs), some azole antifungals, sulfa drugs, probenecid, monoamine oxidase inhibitors (MAOIs), beta-blockers, and seizure medications.

Tradjenta may also interact with bosentan, dexamethasone, quinidine, verapamil, rifabutin, rifampin, rifapentine, St. John's wort, barbiturates, medication to treat HIV/AIDS, medicines to treat narcolepsy, medicines used to prevent organ transplant rejection, aspirin or other salicylates (including Pepto-Bismol), or other oral diabetes medications.

Glucotrol may also interact with alcohol, and other drugs that are highly protein bound, salicylates, chloramphenicol, coumarins, quinolones, diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, nicotinic acid, sympathomimetics, calcium channel blockers, colesevelam, and isoniazid.

What Are Possible Side Effects of Tradjenta?

Common side effects of Tradjenta include:

Tradjenta may cause serious side effects, including:

  • inflammation of the pancreas (pancreatitis, symptoms include severe pain in your upper stomach spreading to your back, nausea and vomiting,
  • loss of appetite,
  • fast heart rate),
  • fever, and headache with a severe blistering, peeling, and red skin rash.

What Are Possible Side Effects of Glucotrol?

Common side effects of Glucotrol include:

  • diarrhea
  • constipation
  • nausea
  • vomiting
  • upset stomach
  • loss of appetite
  • headache
  • weight gain,
  • skin changes (skin rash, hives, redness, itching, and blisters)
  • gas
  • drowsiness, and
  • dizziness

Tell your doctor if you experience serious side effects of Glucotrol including easy bruising or bleeding (nosebleeds, bleeding gums), tiredness, shortness of breath, upper stomach pain, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); pale skin, fever, confusion; or throbbing headache, severe nausea and vomiting, fast or pounding heartbeats, sweating or thirst, or feeling like you might pass out.

What Is Tradjenta?

Tradjenta (linagliptin) tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

What Is Glucotrol?

Glucotrol (glipizide) is blood glucose lowering drug of the sulfonylurea class used to help maintain glucose control in type 2 diabetics, in conjunction with an appropriate diet and exercise program. Glucotrol is available as a generic named glipizide.


Type 2 Diabetes: Signs, Symptoms, Treatments See Slideshow

What Drugs Interact With Tradjenta?

Tradjenta may interact with bosentan, dexamethasone, ketoconazole, quinidine, verapamil, rifabutin, rifampin, rifapentine, St. John's wort, phenobarbital and other barbiturates, medication to treat HIV or AIDS, medicines to treat narcolepsy, medicines used to prevent organ transplant rejection, seizure medications, probenecid, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates (including Pepto-Bismol), sulfa drugs, monoamine oxidase inhibitors (MAOIs), beta-blockers, or other oral diabetes medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Tradjenta; it is not expected to harm an unborn baby. It is unknown if Tradjenta passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

What Drugs Interact With Glucotrol?

Many drugs may interact with Glucotrol; patients should carefully check glucose levels and inform their doctors about what medications they are taking. There are no adequate and well controlled studies of Glucotrol in pregnant women. Glucotrol (glipizide) should be used during pregnancy or breastfeeding women only if the potential benefit justifies the potential risk to the fetus and infant.

How Should Tradjenta Be Taken?

The recommended dose of Tradjenta is 5 mg once daily.

How Should Glucotrol Be Taken?

Glucotrol is available in 5 and 10 mg strength tablets. The usual starting dose is 5 mg about 30 min before breakfast.


______________ is another term for type 2 diabetes. See Answer

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Boehringer Ingelheim Pharmaceuticals, Inc. Tradjenta Product Information.
Pfizer. Glucotrol Product Information.

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