Transaminase clinical usage: Two of the better known enzymes in the transaminase class are serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT). Both SGOT and SGPT are normally found primarily in liver and heart cells, are released into the bloodstream as the result of liver or heart damage, and so serve as tests of the liver and heart. The levels of these transaminases are elevated by liver disease (for example, viral hepatitis) or by an insult to the heart (for example, a heart attack). Some medications can also raise the levels of these transaminases. The interpretation of elevated SGOT and SGPT levels depends upon the context and can necessitate additional clinical and laboratory information.