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Transderm Nitro

Last reviewed on RxList: 3/30/2009
Transderm Nitro Side Effects Center

Last reviewed on RxList 1/10/2016

Transderm-Nitro (nitroglycerin) Transdermal Therapeutic System is a nitrate used to prevent attacks of chest pain (angina). The brand name Transderm-Nitro is discontinued in the U.S. Generic forms may be available. Common side effects of Transderm-Nitro include headache, dizziness, lightheadedness, nausea, vomiting, upset stomach, nervousness, weakness, skin rash or itching, and flushing (warmth, redness, or tingly feeling under your skin) as your body adjusts to this medication.

The suggested starting dose of nitroglycerin is between 0.2 mg/hr, and 0.4 mg/hr. Doses between 0.4 mg/hr and 0.8 mg/hr have shown continued effectiveness for 10-12 hours daily for at least one month of intermittent administration. An appropriate dosing schedule for nitroglycerin patches would include a daily patch-on period of 12-14 hours and a daily patch-off period of 10-12 hours. Nitroglycerin may interact with blood pressure medication, diuretics (water pills), cold or allergy medicines, diet pills, over-the-counter pain medicine, erectile dysfunction medications, migraine headache medications, beta-blockers, or calcium channel blockers. Tell your doctor all medications you use. During pregnancy, nitroglycerin should be used only when prescribed. It is unknown if this drug passes into breast milk or if it may harm a nursing infant. Consult your doctor before breastfeeding.

Our Transderm-Nitro (nitroglycerin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Transderm Nitro Consumer Information

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use nitroglycerin transdermal. Do not stop using the medication. Ask your doctor before using any headache pain medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • worsening chest pain, slow heart rate;
  • feeling like you might pass out;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • fast or pounding heartbeats; or
  • blurred vision and dry mouth.

Less serious side effects may include:

  • mild skin rash or itching;
  • warmth, redness, or tingly feeling under your skin;
  • nausea, vomiting, upset stomach; or
  • feeling nervous, weak, or dizzy.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Transderm Nitro (Nitroglycerin)

Transderm Nitro Professional Information


Adverse reactions to nitroglycerin are generally dose-related, and almost all of these reactions are the result of nitroglycerin.s activity as a vasodilator. Headache, which may be severe, is the most commonly reported side effect. Headache may be recurrent with each daily dose, especially at higher doses. Transient episodes of lightheadedness, occasionally related to blood pressure changes, may also occur. Hypotension occurs infrequently, but in some patients it may be severe enough to warrant discontinuation of therapy. Syncope, crescendo angina, and rebound hypertension have been reported but are uncommon.

Allergic reactions to nitroglycerin are also uncommon, and the great majority of those reported have been cases of contact dermatitis or fixed drug eruptions in patients receiving nitroglycerin in ointments or patches. There have been a few reports of genuine anaphylactoid reactions, and these reactions can probably occur in patients receiving nitroglycerin by any route.

Extremely rarely, ordinary doses of organic nitrates have caused methemoglobinemia in normal-seeming patients. Methemoglobinemia is so infrequent at these doses that further discussion of its diagnosis and treatment is deferred (see OVERDOSAGE).

Application-site irritation may occur but is rarely severe.

In two placebo-controlled trials of intermittent therapy with nitroglycerin patches at 0.2 to 0.8 mg/hr, the most frequent adverse reactions among 307 subjects were as follows:

  Placebo Patch
Headache 18% 63%
Lightheadedness 4% 6%
Hypotension, and/or syncope 0% 4%
Increased angina 2% 2%

Read the entire FDA prescribing information for Transderm Nitro (Nitroglycerin)

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© Transderm Nitro Patient Information is supplied by Cerner Multum, Inc. and Transderm Nitro Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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