Transderm Scop

Last reviewed on RxList: 3/1/2021
Transderm Scop Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Transderm Scop?

Transderm Scop (transdermal scopolamine) is an anticholinergic drug patch applied to the skin used to prevent nausea and vomiting caused by motion sickness or from anesthesia given during surgery.

What Are Side Effects of Transderm Scop?

Side effects of Transderm Scop include:

  • dry mouth,
  • dry or itchy eyes,
  • drowsiness,
  • dizziness,
  • feeling restless,
  • memory problems, or
  • itching or skin rash.

Dosage for Transderm Scop

To prevent the nausea and vomiting associated with motion sickness, a dose of one Transderm Scop patch (formulated to deliver approximately 1mg of scopolamine over 3 days) should be applied to the hairless area behind one ear at least 4 hours before the antiemetic effect is required. To prevent postoperative nausea and vomiting, a dose of one Transderm Scop patch should be applied the evening before scheduled surgery, except for caesarian section.

What Drugs, Substances, or Supplements Interact with Transderm Scop?

Transderm Scop may interact with other medicines that make you sleepy (such as cold or allergy medicines, sedatives, narcotic pain medicines, sleeping pills, muscle relaxers, and medicines for seizures, depression, or anxiety). Transderm Scop slows the digestive tract, which can make it harder for your body to absorb any medicines you take by mouth. Tell your doctor all medications and supplements you use.

Transderm Scop During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant while using Transderm Scop; it is unknown if Transderm Scop transdermal will harm a fetus. Transderm Scop passes into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding

Additional Information

Our Transderm scop Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Transderm Scop Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives, rash, skin redness; difficulty breathing; swelling of your face, lips, tongue, or throat.

Remove the skin patch and call your doctor at once if you have:

  • severe dizziness;
  • confusion, agitation, extreme fear, hallucinations, unusual thoughts or behavior;
  • a seizure;
  • eye pain or redness, blurred vision, dilated pupils;
  • decreased urination, painful or difficult urination; or
  • stomach pain, nausea, vomiting.

Serious side effects may be more likely in older adults.

Common side effects may include:

  • dry mouth, sore throat;
  • blurred vision or other eye problems;
  • drowsiness, dizziness;
  • confusion; or
  • feeling agitated or irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Transderm Scop (Scopolamine)


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Transderm Scop Professional Information


The following serious adverse reactions are described elsewhere in labeling:

  • Acute Angle Closure Glaucoma [see WARNINGS AND PRECAUTIONS]
  • Neuropsychiatric Adverse Reactions [see WARNINGS AND PRECAUTIONS]
  • Eclamptic Seizures in Pregnant Women [see WARNINGS AND PRECAUTIONS]
  • Gastrointestinal and Urinary Disorders [see WARNINGS AND PRECAUTIONS]
  • Drug Withdrawal/Post-Removal Symptoms [see WARNINGS AND PRECAUTIONS]
  • Blurred Vision [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Motion Sickness

The most common adverse reaction (approximately two thirds) was dry mouth. Less common adverse reactions, included drowsiness (less than one sixth), blurred vision and dilation of the pupils.


Common adverse reactions, occurring in at least 3% of patients in PONV clinical trials are shown in Table 1.

Table 1 Common Adverse Reactions* in Surgical Patients for the Prevention of PONV

  Transderm Scop
% (N = 461)
% (N = 457)
Dry mouth 29 16
Dizziness 12 7
Somnolence 8 4
Agitation 6 4
Visual Impairment 5 3
Confusion 4 3
Mydriasis 4 0
Pharyngitis 3 2
*occurring in at least 3% of patients and at a rate higher than placebo

Postmarketing Experience

The following adverse reactions have been identified during post-approval use of scopolamine transdermal system. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Psychiatric disorders: acute psychosis including: hallucinations, disorientation, and paranoia

Nervous system disorders: headache, amnesia, coordination abnormalities, speech disorder, disturbance in attention, restlessness

General disorders and administration site conditions: application site burning

Eye disorders: dry eyes, eye pruritus, angle closure glaucoma, amblyopia, eyelid irritation

Skin and subcutaneous tissue disorders: rash generalized, skin irritation, erythema

Renal and urinary disorders: dysuria

Ear and labyrinth disorders: vertigo

Read the entire FDA prescribing information for Transderm Scop (Scopolamine)

© Transderm Scop Patient Information is supplied by Cerner Multum, Inc. and Transderm Scop Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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