Last updated on RxList: 4/23/2021
Tranxene Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Tranxene?

Tranxene (clorazepate dipotassium) is a benzodiazepine used to treat anxiety, seizure disorders, and alcohol withdrawal symptoms. Tranxene is available in a generic form.

What Are Side Effects of Tranxene?

Common side effects of Tranxene include:

  • dizziness,
  • drowsiness,
  • tiredness,
  • fatigue,
  • blurred vision,
  • sleep problems (insomnia),
  • nausea,
  • vomiting,
  • stomach pain,
  • upset stomach,
  • constipation,
  • dry mouth,
  • headache,
  • amnesia or forgetfulness,
  • muscle weakness,
  • lack of balance or coordination,
  • nervousness,
  • irritability, or
  • skin rash.

Serious side effects of Tranxene include:

  • confusion,
  • depression,
  • suicide ideation,
  • muscle tremors,
  • dependence and
  • urinary problems.

Dosage for Tranxene

Tranxene (clorazepate dipotassium) is available in strengths of 3.75, 7.5 and 15 mg tablets. The starting dose is usually 30mg but may vary according to the type of problem treated; doctors should prescribe the dose.

What Drugs, Substances, or Supplements Interact with Tranxene?

Tranxene may interact with alcohol, barbiturates, MAO inhibitors, medicines to treat psychiatric disorders, narcotics, or antidepressants. Tell your doctor all medications and supplements you use.

Tranxene During Pregnancy and Breastfeeding

Pregnant or breastfeeding women should either stop or do not start using Tranxene due to potential harm to the fetus or infant. The drug is not recommended for use in patients less than 9 years of age.

Additional Information

Our Tranxene Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Tranxene Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Clorazepate can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing. A person caring for you should seek emergency medical attention if you have weak or shallow breathing, if you are hard to wake up, or if you stop breathing.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • severe drowsiness;
  • confusion, unusual thoughts or behavior; or
  • problems with urination.

The sedative effects of clorazepate may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking clorazepate.

Common side effects may include:

  • dizziness, drowsiness;
  • blurred vision;
  • upset stomach; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Tranxene (Clorazepate Dipotassium)


Panic attacks are repeated attacks of fear that can last for several minutes. See Answer
Tranxene Professional Information


The side effect most frequently reported was drowsiness. Less commonly reported (in descending order of occurrence) were: dizziness, various gastrointestinal complaints, nervousness, blurred vision, dry mouth, headache, and mental confusion. Other side effects included insomnia, transient skin rashes, fatigue, ataxia, genitourinary complaints, irritability, diplopia, depression, tremor, and slurred speech.

There have been reports of abnormal liver and kidney function tests and of decrease in hematocrit.

Decrease in systolic blood pressure has been observed.

To report SUSPECTED ADVERSE REACTIONS, contact Recordati Rare Diseases Inc. at 1-888-575- 8344 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Tranxene (Clorazepate Dipotassium)

© Tranxene Patient Information is supplied by Cerner Multum, Inc. and Tranxene Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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