Tranxene Side Effects Center

Last updated on RxList: 9/28/2022
Tranxene Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Tranxene?

Tranxene (clorazepate dipotassium) is a benzodiazepine used to treat anxiety, seizure disorders, and alcohol withdrawal symptoms. Tranxene is available in a generic form.

What Are Side Effects of Tranxene?

Tranxene may cause serious side effects including:

  • mood or behavior changes,
  • anxiety,
  • panic attacks,
  • trouble sleeping,
  • impulsive behavior,
  • irritableness,
  • agitation,
  • hostility,
  • aggression,
  • restlessness,
  • hyperactive (mentally or physically),
  • increased depression,
  • suicidal thought,
  • confusion,
  • unusual thoughts or behavior,
  • problems with urination, and
  • lightheadedness

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Tranxene include:

  • dizziness,
  • drowsiness,
  • tiredness,
  • fatigue,
  • blurred vision,
  • sleep problems (insomnia),
  • nausea,
  • vomiting,
  • stomach pain,
  • upset stomach,
  • constipation,
  • dry mouth,
  • headache,
  • amnesia or forgetfulness,
  • muscle weakness,
  • lack of balance or coordination,
  • nervousness,
  • irritability, or
  • skin rash.

Serious side effects of Tranxene include:

  • confusion,
  • depression,
  • suicide ideation,
  • muscle tremors,
  • dependence and
  • urinary problems.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Tranxene

Tranxene (clorazepate dipotassium) is available in strengths of 3.75, 7.5 and 15 mg tablets. The starting dose is usually 30mg but may vary according to the type of problem treated; doctors should prescribe the dose.

What Drugs, Substances, or Supplements Interact with Tranxene?

Tranxene may interact with alcohol, barbiturates, MAO inhibitors, medicines to treat psychiatric disorders, narcotics, or antidepressants. Tell your doctor all medications and supplements you use.

Tranxene During Pregnancy and Breastfeeding

Pregnant or breastfeeding women should either stop or do not start using Tranxene due to potential harm to the fetus or infant. The drug is not recommended for use in patients less than 9 years of age.

Additional Information

Our Tranxene Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Panic attacks are repeated attacks of fear that can last for several minutes. See Answer
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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Clorazepate can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • severe drowsiness;
  • slow breathing (breathing may stop);
  • confusion, paranoia, unusual thoughts or behavior;
  • a seizure; or
  • suicidal thoughts or actions.

Drowsiness or dizziness may last longer in older adults. Use caution to avoid falling or accidental injury.

Common side effects may include:

  • dizziness, drowsiness;
  • blurred vision;
  • upset stomach; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Anxiety Disorder Pictures: Symptoms, Panic Attacks, and More with Pictures See Slideshow
Tranxene Professional Information


The side effect most frequently reported was drowsiness. Less commonly reported (in descending order of occurrence) were: dizziness, various gastrointestinal complaints, nervousness, blurred vision, dry mouth, headache, and mental confusion. Other side effects included insomnia, transient skin rashes, fatigue, ataxia, genitourinary complaints, irritability, diplopia, depression, tremor, and slurred speech.

There have been reports of abnormal liver and kidney function tests and of decrease in hematocrit.

Decrease in systolic blood pressure has been observed.

To report SUSPECTED ADVERSE REACTIONS, contact Recordati Rare Diseases Inc. at 1-888-575- 8344 or FDA at 1-800-FDA-1088 or

Read the entire FDA prescribing information for Tranxene (Clorazepate)

© Tranxene Patient Information is supplied by Cerner Multum, Inc. and Tranxene Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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