Trecator

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 9/7/2021
Trecator Side Effects Center

What Is Trecator?

Trecator (ethionamide) is an antibiotic used to treat tuberculosis (TB).

What Are Side Effects of Trecator?

Common side effects of Trecator include:

Dosage for Trecator

The usual adult dose of Trecator is 15 to 20 mg/kg/day, administered once daily or, if patient exhibits poor gastrointestinal tolerance, in divided doses, with a maximum daily dosage of 1 gram.

What Drugs, Substances, or Supplements Interact with Trecator?

Trecator may interact with cycloserine or isoniazid. Tell your doctor all medications and supplements you use.

Trecator During Pregnancy and Breastfeeding

Trecator is not recommended for use during pregnancy. It may harm a fetus. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Trecator (ethionamide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Bowel regularity means a bowel movement every day. See Answer
Trecator Consumer Information

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • numbness, tingling, or burning pain in your hands or feet;
  • confusion; unusual thoughts or behavior;
  • eye pain, blurred vision, double vision;
  • a light-headed feeling, like you might pass out;
  • seizure (convulsions); or
  • upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • nausea, vomiting, diarrhea;
  • stomach pain, loss of appetite;
  • increased salivation, metallic taste in your mouth;
  • blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
  • headache, dizziness; or
  • drowsiness, depressed mood, restless feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Trecator (Ethionamide Tablets)

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Trecator Professional Information

SIDE EFFECTS

Gastrointestinal

The most common side effects of ethionamide are gastrointestinal disturbances including nausea, vomiting, diarrhea, abdominal pain, excessive salivation, metallic taste, stomatitis, anorexia and weight loss. Adverse gastrointestinal effects appear to be dose related, with approximately 50% of patients unable to tolerate 1 gm as a single dose. Gastrointestinal effects may be minimized by decreasing dosage, by changing the time of drug administration, or by the concurrent administration of an antiemetic agent.

Nervous System

Psychotic disturbances (including mental depression), drowsiness, dizziness, restlessness, headache, and postural hypotension have been reported with ethionamide. Rare reports of peripheral neuritis, optic neuritis, diplopia, blurred vision, and a pellagra-like syndrome also have been reported. Concurrent administration of pyridoxine has been recommended to prevent or relieve neurotoxic effects.

Hepatic

Transient increases in serum bilirubin, SGOT, SGPT; Hepatitis (with or without jaundice).

Other

Hypersensitivity reactions including rash, photosensitivity, thrombocytopenia and purpura have been reported rarely. Hypoglycemia, hypothyroidism, gynecomastia, impotence, and acne also have occurred. The management of patients with diabetes mellitus may become more difficult in those receiving ethionamide.

Read the entire FDA prescribing information for Trecator (Ethionamide Tablets)

© Trecator Patient Information is supplied by Cerner Multum, Inc. and Trecator Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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