Tremfya vs. Skyrizi

Are Tremfya and Skyrizi the Same Thing?

Tremfya (guselkumab) injection and Skyrizi (risankizumab-rzaa) are interleukin-23 blockers used to treat adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Side effects of Tremfya and Skyrizi that are similar include upper respiratory infections, headache, injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and tinea infections (ringworm, athlete's foot and jock itch).

Side effects of Tremfya that are different from Skyrizi include joint pain, diarrhea, gastroenteritis (nausea, vomiting, diarrhea, cramps, and fever), and herpes simplex infections.

Side effects of Skyrizi that are different from Tremfya include fatigue.

Both Tremfya and Skyrizi may interact with "live" vaccines.

Tremfya may also interact with and CYP450 substrates.

What Are Possible Side Effects of Tremfya?

Common side effects of Tremfya include:

  • upper respiratory infections,
  • headache,
  • injection site reactions,
  • joint pain,
  • diarrhea,
  • gastroenteritis (nausea, vomiting, diarrhea, cramps, and fever),
  • tinea infections (athlete's foot, ringworm, jock itch), and
  • herpes simplex infections

What Are Possible Side Effects of Skyrizi?

Common side effects of Skyrizi include

  • upper respiratory infections,
  • headache,
  • fatigue,
  • injection site reactions (bruising, redness, fluid leakage, bleeding, infection, inflammation, irritation, pain, itching, swelling, warmth), and
  • tinea infections (such as ringworm, athlete's foot and jock itch)

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow

What Is Tremfya?

Tremfya (guselkumab) injection, for subcutaneous use is an interleukin-23 blocker indicated for the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

What Is Skyrizi?

Skyrizi (risankizumab-rzaa) is an interleukin-23 antagonist indicated for the treatment of moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

What Drugs Interact With Tremfya?

Tremfya may interact with "live" vaccines and CYP450 substrates. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Tremfya; it is unknown how it would affect a fetus. Human IgG antibodies are known to cross the placental barrier; therefore, Tremfya may be transmitted from the mother to the developing fetus. It is unknown if Tremfya passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Skyrizi?

Skyrizi may interact with "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received.

How Should Tremfya be Taken?

The dose of Tremfya is 100 mg administered by subcutaneous injection at Week 0, Week 4 and every 8 weeks thereafter.

How Should Skyrizi be Taken?

The dose of Skyrizi is 150 mg (two 75 mg injections) administered by subcutaneous injection at Week 0, Week 4 and every 12 weeks thereafter.

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Janssen Biotech, Inc. Tremfya Product Information.

www.tremfya.com/

Abbvie. Skyrizi Product Information.

www.skyrizi.com/

Health Solutions From Our Sponsors