Trental Side Effects Center

Last updated on RxList: 3/22/2021
Trental Side Effects Center

What Is Trental?

Trental (pentoxifylline) is a hemorrheologic agent (an agent that affects blood viscosity) used to improve blood flow. Improved blood flow helps reduce leg cramps and other symptoms of vascular disease (disease related to veins and arteries). Trental is available in generic form.

What Are Side Effects of Trental?

Common side effects of Trental include:

  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • belching,
  • upset stomach,
  • diarrhea,
  • dizziness,
  • headache,
  • blurred vision, or
  • flushing (warmth, redness, or tingly feeling).

Tell your doctor if you have serious side effects of Trental including:

  • chest pain,
  • fast or irregular heartbeat,
  • easy bruising or bleeding,
  • feeling like you might pass out,
  • red or pink urine,
  • bloody or tarry stools, or
  • coughing up blood or vomit.

Dosage for Trental

The usual dosage of Trental in extended-release tablet form is one tablet (400 mg) three times a day with meals. It is recommended treatment is continued for at least 8 weeks.

What Drugs, Substances, or Supplements Interact with Trental?

Trental may interact with blood thinners, theophylline, aminophylline, dyphylline, and oxtriphylline. Tobacco may worsen your condition or decrease the beneficial effects of Trental by narrowing your blood vessels. Talk to your doctor if you use tobacco. Tell your doctor all medications you use.

Trental During Pregnancy and Breastfeeding

During pregnancy, Trental should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Trental (pentoxifylline) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Trental Consumer Information

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Stop taking pentoxifylline and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain;
  • pounding heartbeats or fluttering in your chest;
  • red or pink urine;
  • a light-headed feeling, like you might pass out; or
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects may include:

  • dizziness, headache;
  • nausea, vomiting;
  • diarrhea, gas; or
  • bloating, upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Trental Professional Information


Clinical Trial Adverse Drug Reactions

Because clinical trials are conducted under very specific conditions the adverse reaction rates observed in the clinical trials may not reflect the rates observed in practice and should not be compared to the rates in the clinical trials of another drug. Adverse drug reaction information from clinical trials is useful for identifying drug-related adverse events and for approximating rates.

The most frequent adverse event reported with Trental (pentoxifylline) is nausea (14%). Individual signs/symptoms listed in the table below occurred at an incidence between 1 and 3%, except when stated otherwise.

Body as a whole Malaise
Cardiovascular system Flushing
Central nervous system Dizziness/light-headedness (9.4%), headache (4.9 %)
Gastrointestinal system Nausea (14%), vomiting (3.4%), abdominal discomfort, bloating, diarrhea, dyspepsia

Less Common Clinical Trial Adverse Drug Reactions ( < 1%)

Body as a whole: Muscle aches/spasm, weight change, backache, bad taste in mouth, leg cramps, fever, weakness, sweating.

Cardiovascular: Chest pain, arrhythmia, hypertension, dyspnea, edema, hypotension, angina, tachycardia.

Central nervous system: Drowsiness/sleepiness, tremor, agitation anxiety, confusion, insomnia, restlessness.

Gastrointestinal: Abdominal burning, abdominal pain, anorexia flatus, constipation, haemorrhage, heartburn, salivation, dry mouth/throat, hepatitis, jaundice, increased liver enzymes.

Hemic and lymphatic: Decreased serum fibrinogen, pancytopenia, purpura, thrombocytopenia, leucopenia, anemia, aplastic anemia.

Hypersensitivity reactions: Pruritis, rash, urticaria, angioedema.

Organs of special sense: Blurred vision, scotoma, lacrimation, epistaxis.

Post-Market Adverse Drug Reactions

Hepatobiliary disorders: Intrahepatic cholestasis.

Immune system disorders: Severe anaphylactic/anaphylactoid reaction with, for example, angioneurotic edema, bronchospasms, sometimes shock.

Infections and infestations: Aseptic meningitis.

Investigations: Transaminase elevation.

Psychiatric: Sleep disturbances.

Skin and subcutaneous tissue disorders: Reddening of skin.

Vascular disorder: Haemorrhage

Read the entire FDA prescribing information for Trental (Pentoxifylline)

© Trental Patient Information is supplied by Cerner Multum, Inc. and Trental Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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