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Last reviewed on RxList: 10/1/2018
Trezix Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 10/1/2018

Trezix (acetaminophen, caffeine, dihydrocodeine bitartrate capsule) contains a non-opiate analgesic and antipyretic, a CNS and cardiovascular stimulant and an analgesic adjuvant, and a narcotic analgesic related to codeine indicated for the relief of moderate to moderately severe pain. Common side effects of Trezix include:

The usual adult dosage is two (2) Trezix capsules orally every four (4) hours, as needed. No more than two (2) Trezix capsules should be taken in a 4-hour period. No more than five (5) Trezix doses, or ten (10) capsules should be taken in a 24-hour period. Trezix may interact with other opioid analgesics, sedatives, hypnotics, muscle relaxants, general anesthetics, centrally acting anti-emetics, phenothiazines or other tranquilizers, alcohol, monoamine oxidase inhibitors (MAOIs), beta-adrenergic stimulating agents, disulfiram, phenobarbital, aspirin, and quinolone antibiotics. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Trezix; it is unknown if it will harm a fetus. Use caution especially during the first trimester. The medications in Trezix pass into breast milk. Because of the potential for serious adverse reactions in nursing infants from this combination product, breastfeeding while using Trezix is not recommended. Withdrawal symptoms may occur if you suddenly stop taking Trezix.

Our Trezix (acetaminophen, caffeine, dihydrocodeine bitartrate capsule) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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The most frequently observed adverse reactions include light-headedness, dizziness, drowsiness, headache, fatigue, sedation, sweating, nausea, vomiting, constipation, pruritus, and skin reactions. With the exception of constipation, tolerance develops to most of these effects. Other reactions that have been observed with dihydrocodeine or other opioids include respiratory depression, orthostatic hypotension, cough suppression, confusion, diarrhea, miosis, abdominal pain, dry mouth, indigestion, anorexia, spasm of biliary tract, and urinary retention. Physical and psychological dependence are possibilities. Hypersensitivity reactions (including anaphylactoid reactions), hallucinations, vivid dreams, granulomatous interstitial nephritis, severe narcosis and acute renal failure have been reported rarely during dihydrocodeine administration.


Acetaminophen in therapeutic doses rarely causes adverse reactions. The most serious adverse reaction is hepatoxicity from overdosage (see OVERDOSE). Thrombocytopenia, leukopenia, pancytopenia, neutropenia, thrombocytopenic purpura, and agranulocytosis have been reported in patients receiving acetaminophen or p-aminophenol derivatives. Hypersensitivity reactions including urticarial or erythematous skin reactions, laryngeal edema, angioedema, or anaphylactoid reactions are rare.


Adverse reactions associated with caffeine use include anxiety, anxiety neurosis, excitement, headaches, insomnia, irritability, lightheadedness, restlessness, tenseness, tremor, extrasystoles, palpitations, tachycardia, diarrhea, nausea, stomach pain, vomiting, diuresis, urticaria, scintillating scotoma, and tinnitus.

Read the entire FDA prescribing information for Trezix (Acetaminophen, Caffeine and Dihydrocodeine Bitartrate)


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© Trezix Patient Information is supplied by Cerner Multum, Inc. and Trezix Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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