Abrojo, Abrojos, Al-Gutub, Baijili, Bulgarian Tribulus Terrestris, Caltrop, Cat's-Head, Ci Ji Li, Common Dubbletjie, Croix-de-Malte, Devil's-Thorn, Devil's-Weed, Espigón, Épine du Diable, Escarbot, German Tribulus Terrestris, Goathead, Gokhru, Gokshur, Gokshura, Nature's Viagra, Puncture Vine, Puncture Weed, Qutiba, Small Caltrops, Tribule, Tribule Terrestre, Tribulis, Tribulis Terrestris, Tribulus terrestris.
Tribulus is a plant that produces fruit covered with spines. Rumor has it that tribulus is also known as puncture vine because the spines are so sharp they can flatten bicycle tires. People use the fruit, leaf, and root as medicine for wide-ranging complaints.
Tribulus is used for kidney problems, including kidney stones, painful urination, a kidney disorder called Bright's disease, and as a “water pill” (diuretic) to increase urination; for skin disorders, including eczema (atopic dermatitis), psoriasis, and scabies; for male sexual problems, including erectile dysfunction (ED), involuntary release of semen without orgasm (spermatorrhea), and to increase sexual desire; for heart and circulatory system problems, including chest pain, high blood pressure, high cholesterol, and “tired blood” (anemia); for problems with digestion, including colic, intestinal gas (flatulence), constipation, and to expel intestinal parasitic worms; for pain and swelling (inflammation) of the tissue lining the mouth (stomatitis) and sore throat; and for cancer, especially nose tumors.
Women use tribulus to tone muscles before childbirth, to cause an abortion, and to stimulate milk flow.
Some people use tribulus for gonorrhea, liver disease (hepatitis), inflammation, joint pain (rheumatism), leprosy, coughs, headache, dizziness (vertigo), chronic fatigue syndrome (CFS), and enhancing athletic performance. It is also used for stimulating appetite and as an astringent, tonic, and mood enhancer.
How does it work?
Tribulus has chemicals that might increase some hormones in animals. However, it doesn't appear to increase male hormones (testosterone) in humans.
Possibly Ineffective for...
- Enhancing athletic performance. Taking tribulus by mouth, alone or in combination with other herbs and supplements such as androstenedione, doesn't seem to enhance body composition or exercise performance in athletes.
- Infertility. Early research suggests that taking a specific tribulus product (Tribestan) by mouth for 30 days improves sperm count, sperm movement, and volume of ejaculate in people with infertility due to low sperm count and reduced sperm movement. Other research suggests that taking this same product by mouth for 1-2 months can increase libido and erections in people who are infertile due to low levels of testosterone (hypogonadism).
Insufficient Evidence to Rate Effectiveness for...
- Chest pain (angina). Developing research suggests a tribulus extract taken by mouth might reduce symptoms of angina.
- Eczema (atopic dermatitis). Tribulus taken by mouth in combination with 9 other herbs (Zemaphyte) might reduce redness and skin outbreaks in adults and children with a certain type of eczema called nonexudative atopic eczema. However, other research shows no effect.
- Erectile dysfunction (ED).
- “Tired blood” (anemia).
- Intestinal gas (flatulence).
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Tribulus supplements are POSSIBLY SAFE for most people when taken by mouth for a short period of time. They have been used safely in research studies lasting up to 8 weeks. The long-term safety of tribulus is unknown.
Eat the spine-covered fruit of tribulus is LIKELY UNSAFE. There has been a report of a serious lung problem linked to eating the fruit.
Prostate problems or prostate cancer: There is a concern that tribulus might make prostate conditions such as benign prostate hypertrophy (BPH) or prostate cancer worse. Developing research suggests that tribulus can increase prostate weight.
Diabetes. Tribulus might decrease blood sugar levels. Dose of diabetes medications might need to be adjusted by your healthcare provider.
Surgery: Tribulus might affect blood sugar levels. This might interfere with blood sugar control during and after surgery. Stop using tribulus at least 2 weeks before a scheduled surgery.
LithiumInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Tribulus might have an effect like a "water pill" or diuretic. Taking tribulus might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Tribulus might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking tribulus along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications for high blood pressure (ACE inhibitors)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Tribulus seems to lower blood pressure. Taking tribulus along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.
Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Tribulus seems to lower blood pressure. Taking tribulus along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
The appropriate dose of tribulus depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for tribulus. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Adimoelja, A. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl 2000;23 Suppl 2:82-84. View abstract.
Ali, N. A., Julich, W. D., Kusnick, C., and Lindequist, U. Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. J Ethnopharmacol. 2001;74(2):173-179. View abstract.
Kohut, M. L., Thompson, J. R., Campbell, J., Brown, G. A., Vukovich, M. D., Jackson, D. A., and King, D. S. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. J Am Coll Nutr 2003;22(5):363-371. View abstract.
Adaikan, P. G., Gauthaman, K., Prasad, R. N., and Ng, S. C. Proerectile pharmacological effects of Tribulus terrestris extract on the rabbit corpus cavernosum. Ann Acad.Med Singapore 2000;29(1):22-26. View abstract.
Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. View abstract.
Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. View abstract.
Anand R, Patnaik GK, Srivastava S, and et al. Evaluation of antiurolithiatic activity of Tribulus terrestris. International Journal of Pharmacognosy 1994;32(3):217-224.
Antonio J, Uelmen J, Rodriguez R, Earnest C. The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab 2000;10:208-15. View abstract.
Bedir, E. and Khan, I. A. New steroidal glycosides from the fruits of Tribulus terrestris. J Nat Prod 2000;63(12):1699-1701. View abstract.
Bedir, E., Khan, I. A., and Walker, L. A. Biologically active steroidal glycosides from Tribulus terrestris. Pharmazie 2002;57(7):491-493. View abstract.
Bourke, C. A., Stevens, G. R., and Carrigan, M. J. Locomotor effects in sheep of alkaloids identified in Australian Tribulus terrestris. Aust.Vet.J 1992;69(7):163-165. View abstract.
Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. View abstract.
Brown GA, Vukovich MD, Martini ER, et al. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. J Am Coll Nutr 2001;20:520-8. View abstract.
Brown GA, Vukovich MD, Reifenrath TA, et al. Effects of anabolic precursors on serum testosterone concentrations and adaptations to resistance training in young men. Int J Sport Nutr Exerc Metab 2000;10:340-59. View abstract.
Conrad, J., Dinchev, D., Klaiber, I., Mika, S., Kostova, I., and Kraus, W. A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. Fitoterapia 2004;75(2):117-122. View abstract.
De Combarieu E, Fuzzati N, Lovati M, Mercalli E. Furostanol saponins from Tribulus terrestris. Fitoterapia 2003;74:583-91. View abstract.
Deepak M, Dipankar G, Prashanth D, et al. Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris. Phytomedicine 2002;9:753-6. View abstract.
Deng, Y., Yang, L., and An, S. L. [Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22(11):1017-1019. View abstract.
Dudley JP. Bilateral pneumothorax resulting from the bronchoscopic removal of a puncture vine fruit. Ann Otol Rhinol Laryngol 1983;92:396-7. View abstract.
Fung AY, Look PC, Chong LY, et al. A controlled trial of traditional Chinese herbal medicine in Chinese patients with recalcitrant atopic dermatitis. Int J Dermatol 1999;38:387-92 . View abstract.
Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002;71:1385-96. View abstract.
Gauthaman K, Adaikan PG. Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J Ethnopharmacol 2005;96:127-32. View abstract.
Glastonbury, J. R., Doughty, F. R., Whitaker, S. J., and Sergeant, E. A syndrome of hepatogenous photosensitisation, resembling geeldikkop, in sheep grazing Tribulus terrestris. Aust Vet J 1984;61(10):314-316. View abstract.
Golik A, Modai D, Averbukh Z, et al. Zinc metabolism in patients treated with captopril versus enalapril. Metabolism 1990;39:665-7. View abstract.
Hong CH, Hur SK, Oh OJ, et al. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002;83:153-9. View abstract.
Huang, J. W., Tan, C. H., Jiang, S. H., and Zhu, D. Y. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res 2003;5(4):285-290. View abstract.
Jacob, R. H. and Peet, R. L. Poisoning of sheep and goats by Tribulis terrestris (caltrop). Aust Vet J 1987;64(9):288-289. View abstract.
Jameel, J. K., Kneeshaw, P. J., Rao, V. S., and Drew, P. J. Gynaecomastia and the plant product "Tribulis terrestris". Breast 2004;13(5):428-430. View abstract.
Joshi, V. S., Parekh, B. B., Joshi, M. J., and Vaidya, A. D. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata. Urol.Res 2005;33(2):80-86. View abstract.
Kumanov F, Bozadzhieva E, Platonova M, and et al. [Clinical testing of Tribestan]. Savr Med 1982;4:211-215.
Li M, Qu W, Wang Y, et al. [Hypoglycemic effect of saponin from Tribulus terrestris] Zhong Yao Cai 2002;25:420-2. View abstract.
Neychev, V. K. and Mitev, V. I. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. J Ethnopharmacol. 2005; Oct 3;101(1-3):319-23 View abstract.
Protich, M., Tsvetkov, D., Nalbanski, B., Stanislavov, R., and Katsarova, M. [Clinical trial of a tribestan preparation in infertile men]. Akush.Ginekol.(Sofiia) 1983;22(4):326-329. View abstract.
Raos, M., Bumber, Z., and Kovac, K. [A bronchial polyp and foreign body in an adolescent]. Lijec.Vjesn. 2001;123(7-8):177-178. View abstract.
Seth, S. D. and Jagadeesh, G. Cardiac action of Tribulus terrestris. Indian J Med Res 1976;64(12):1821-1825. View abstract.
Seth, S. D. and Prabhakar, M. C. Preliminary pharmacological investigations of Tribulus terrestris, Linn. (Gokhru) part 1. Indian J Med Sci 1974;28(9):377-380. View abstract.
Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. View abstract.
Sheehan M, Rustin MHA, Atherton DJ, et al. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Lancet 1992;340:13-17. View abstract.
Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Br J Dermatol 1992;126:179-84. View abstract.
Sun, B., Qu, W. J., Zhang, X. L., Yang, H. J., Zhuang, X. Y., and Zhang, P. [Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402]. Zhongguo Zhong.Yao Za Zhi. 2004;29(7):681-684. View abstract.
Sun, B., Qu, W., and Bai, Z. [The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro]. Zhong.Yao Cai. 2003;26(2):104-106. View abstract.
Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
Tsetkov D., Karapandov M., and Taskov M. [Vitation: Effect on some forms of male infertility]. Med-Biol Inf 1988;1:27-30.
Twaij HA, Elisha EE, Khalid RM, and et al. Analgesic studies on some Iraqi medicinal plants. International Journal of Crude Drug Research 1987;25(4):251-254.
Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. View abstract.
Wang B, Ma L, Liu T. 406 cases of angina pectoris in coronary heart disease treated with saponin of Tribulus terrestris. Chung Hsi I Chieh Ho Tsa Chih 1990;10:85-7. View abstract.
Wilkins AL, et al. Photosensitivity in South Africa. IX. Structure elucidation of a beta-glucosidase-treated saponin from Tribulus terrestis, and the identification of saponin chemotypes of South African T. terrestis. Onderstepoort Journal Veterinary Res 1996; 63:327-34. View abstract.
Zarkova S. [Steroid saponins of Tribulus terrestris L. have a stimulant effect on the sexual function]. Rev Port Ciencias Vet 1984;79(470):117-126.
Zhang W, Leonard T, Bath-Hextall F, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev 2004;4:CD002291. View abstract.