Slideshows Images Quizzes
font size

Tricyclic Antidepressants (TCAs) (cont.)

Pharmacy Author:
Medical Editor:

With which drugs do tricyclic antidepressants interact?

Tricyclic antidepressants should not be used with monoamine oxidase inhibiting drugs [for example, tranylcypromine (Parnate)]. High fever, convulsions, and even death can occur from such combinations.

Epinephrine (Primatene, Adrenalin, Ana-Kit, EpiPen, Marcaine) should not be used with tricyclic antidepressants, since together they can cause severe high blood pressure.

Alcohol blocks the antidepressant action of tricyclic antidepressants but increases its sedative effect.

Cimetidine (Tagamet) can increase blood levels and side effects of tricyclic antidepressants.

Combining tricyclic antidepressants with drugs that block acetylcholine can stop bowel movements and paralyze the intestine (paralytic ileus). Dangerous elevations in blood pressure may occur if TCA are combined with clonidine (Catapres, Catapres-TTS).

Medically Reviewed by a Doctor on 5/5/2016

Emotional Wellness

Get tips on therapy and treatment.

Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations

Health Solutions From Our Sponsors