Medical Editor: John P. Cunha, DO, FACOEP
Triesence (triamcinolone acetonide) Injectable Suspension is a steroid injection used to treat inflammation of the joints or tendons to treat arthritis, bursitis, or epicondylitis (tennis elbow). Triesence is usually given in these conditions only as a short-term treatment of a severe or aggravated episode. Triesence is also injected into soft tissues of the body to treat certain skin disorders caused by autoimmune conditions such as lupus, psoriasis, lichen planus, and others. Common side effects of Triesence include:
- appetite changes
- stomach or side pain
- sleep problems (insomnia)
- scaling or other skin changes
- a wound that is slow to heal
- thinning hair
- bruising or swelling
- sweating more than usual, or
- irregular menstrual periods
The initial recommended dose of Triesence suspension is 4 mg (100 microliters of 40 mg/mL suspension) with subsequent dosage as needed over the course of treatment. Triesence may interact with birth control pills or hormone replacement therapy, blood thinners, cyclosporine, digoxin, insulin or oral diabetes medications, isoniazid, rifampin, seizure medications, antibiotics, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Tell your doctor all medications and supplements you use. During pregnancy, Triesence should be used only if prescribed. This drug can pass into breast milk and may harm a nursing baby. Do not breastfeed while you are using Triesence.
Our Triesence (triamcinolone acetonide) Injectable Suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fast, slow, or uneven heart rate;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain;
- dangerously high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain);
- problems with your vision;
- eye swelling, redness, discomfort, or drainage (may be signs of infection);
- severe depression, changes in mood or behavior;
- seizure (convulsions); or
- muscle pain, tenderness, or weakness.
Less serious side effects may include:
- nausea, bloating, appetite changes;
- stomach or side pain;
- headache, sleep problems (insomnia);
- acne, scaling, or other skin changes;
- a wound that is slow to heal;
- thinning hair;
- bruising or swelling;
- sweating more than usual; or
- irregular menstrual periods.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Triesence (Triamcinolone Acetonide Injectable Suspension)
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Adverse event data were collected from 300 published articles containing data from controlled and uncontrolled clinical trials which evaluated over 14,000 eyes treated with different concentrations of triamcinolone acetonide.
The most common dose administered within these trials was triamcinolone acetonide 4 mg administered as primary or adjunctive therapy primarily as a single injection. The most common reported adverse events following administration of triamcinolone acetonide were elevated intraocular pressure and cataract progression. These events have been reported to occur in 20-60% of patients.
Less common reactions occurring in up to 2% include endophthalmitis (infectious and non-infectious), hypopyon, injection site reactions (described as blurring and transient discomfort), glaucoma, vitreous floaters, and detachment of retinal pigment epithelium, optic disc vascular disorder, eye inflammation, conjunctival hemorrhage and visual acuity reduced. Cases of exophthalmos have also been reported.
Common adverse reactions for systemically administered corticosteroids include fluid retention, alteration in glucose tolerance, elevation in blood pressure, behavioral and mood changes, increased appetite and weight gain.
Other reactions reported to have occurred with the administration of corticosteroids include:
Allergic Reactions: Anaphylactoid reaction, anaphylaxis, angioedema
Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis
Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scalp, edema, facial erythema, hyper or hypo-pigmentation, impaired wound healing, increased sweating, petechiae and ecchymoses, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria
Endocrine: Abnormal fat deposits, decreased carbohydrate tolerance, development of Cushingoid state, hirsutism, manifestations of latent diabetes mellitus and increased requirements for insulin or oral hypoglycemic agents in diabetics, menstrual irregularities, moon facies, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness), suppression of growth in children
Fluid and Electrolyte Disturbances: Potassium loss, hypokalemic alkalosis, sodium retention
Gastrointestinal: Abdominal distention, elevation in serum liver enzymes levels (usually reversible upon discontinuation), hepatomegaly, hiccups, malaise, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, ulcerative esophagitis
Metabolic: Negative nitrogen balance due to protein catabolism
Musculoskeletal: Aseptic necrosis of femoral and humeral heads, charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures
Neurological: Arachnoiditis, convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually following discontinuation of treatment, insomnia, meningitis, neuritis, neuropathy, paraparesis/paraplegia, paresthesia, sensory disturbances, vertigo
Reproductive: Alteration in motility and number of spermatozoa.
Read the entire FDA prescribing information for Triesence (Triamcinolone Acetonide Injectable Suspension)
© Triesence Patient Information is supplied by Cerner Multum, Inc. and Triesence Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.