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Triglide

Last reviewed on RxList: 3/7/2017
Triglide Side Effects Center

Last reviewed on RxList 4/28/2015

Triglide (fenofibrate) helps reduce cholesterol and triglycerides (fatty acids) in the blood and is used to treat high cholesterol and high triglyceride levels. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). Common side effects of Triglide include stomach pain, back pain, headache, or runny or stuffy nose. Many people using Triglide do not have serious side effects. Triglide may infrequently cause gallstones and liver problems. If you have severe side effects of Triglide including severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, or dark urine, tell your doctor.

The dose of Triglide to treat primary hypercholesterolemia or mixed dyslipidemia is 160 mg once daily. Triglide may interact with blood thinners, cyclosporine, or other cholesterol-lowering medicines. Tell your doctor all medications you use. Triglide is not recommended during pregnancy. It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended.

Our Triglide (fenofibrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Triglide Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, fenofibrate can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Stop using fenofibrate and call your doctor at once if you have:

  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
  • pain, swelling, warmth, or redness in one or both legs.

Common side effects may include:

  • mild stomach pain;
  • back pain;
  • headache; or
  • runny or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Triglide (Fenofibrate)

Triglide Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect rates observed in clinical practice.

Adverse reactions reported by 2% or more of patients treated with fenofibrate (and greater than placebo) during double-blind, placebo-controlled trials are listed in Table 1. Adverse reactions led to discontinuation of treatment in 5.0% of patients treated with fenofibrate and in 3.0% treated with placebo. Increases in liver function tests were the most frequent events, causing discontinuation of fenofibrate treatment in 1.6% of patients in double-blind trials.

Table 1: Adverse Reactions Reported by 2% or More of Patients Treated with Fenofibrate and Greater than Placebo During the Double-Blind, Placebo-Controlled Trials

BODY SYSTEM
Adverse Reaction
Fenofibrate*
(N=439)
Placebo
(N=365)
  Abdominal Pain 4.6% 4.4%
  Back Pain 3.4% 2.5%
  Headache 3.2% 2.7%
DIGESTIVE
  Nausea 2.3% 1.9%
  Constipation 2.1% 1.4%
METABOLIC AND NUTRITIONAL DISORDERS
  Abnormal Liver Tests 7.5%** 1.4%
  Increased AST 3.4%** 0.5%
  Increased ALT 3.0% 1.6%
  Increased Creatine Phosphokinase 3.0% 1.4%
RESPIRATORY
  Respiratory Disorder 6.2% 5.5%
  Rhinitis 2.3% 1.1%
* Dosage equivalent to 200 mg fenofibrate capsules, micronized. Dosage comparable to 160 mg Triglide.
** Significantly different from placebo.

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of fenofibrate: myalgia, rhabdomyolysis, pancreatitis, muscle spasms, acute renal failure, hepatitis, cirrhosis, anemia, arthralgia, asthenia, and severely depressed HDL-cholesterol levels. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the entire FDA prescribing information for Triglide (Fenofibrate)

Related Resources for Triglide

Read the Triglide User Reviews »

© Triglide Patient Information is supplied by Cerner Multum, Inc. and Triglide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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