Trikafta vs. Kalydeco

Reviewed on 11/16/2020

Are Trikafta and Kalydeco the Same Thing?

Trikafta (elexacaftor, tezacaftor and ivacaftor tablets; ivacaftor tablets) and Kalydeco (ivacaftor) contain CFTR potentiators used to treat different forms of cystic fibrosis (CF).

Trikafta is used to treat used to treat cystic fibrosis in patients aged 12 years and older who have at least one F508del mutation in the CFTR gene. If the patient's genotype is unknown, an FDA-cleared CF mutation test should be used to confirm the presence of at least one F508del mutation.

Kalydeco is used to treat a rare form of cystic fibrosis (CF) in patients ages 6 years and older who have the specific G551D mutation in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene.

Side effects of Trikafta and Kalydeco that are similar include headache, upper respiratory tract infection, stomach/abdominal pain, diarrhea, rash, and cold symptoms (stuffy nose, sneezing, sore throat, post-nasal drip).

Side effects of Trikafta that are different from Kalydeco include influenza, increased alanine aminotransferase, increased blood creatine phosphokinase, increased aspartate aminotransferase, and increased blood bilirubin.

Side effects of Kalydeco that are different from Trikafta include stomach pain, nausea, acne, dizziness, and joint or muscle pain.

Both Trikafta and Kalydeco may interact with antibiotics and antifungals.

Trikafta may also interact with rifampin, rifabutin, seizure medications, St. John's wort, glimepiride and glipizide, digoxin, cyclosporine, everolimus, sirolimus, tacrolimus, statins, glyburide, nateglinide, and repaglinide.

What Are Possible Side Effects of Trikafta?

Common side effects of Trikafta include:

  • headache,
  • upper respiratory tract infection,
  • abdominal pain,
  • diarrhea,
  • rash,
  • increased alanine aminotransferase,
  • runny or stuffy nose,
  • increased blood creatine phosphokinase,
  • increased aspartate aminotransferase,
  • sneezing or post-nasal drip,
  • influenza,
  • sinusitis, and
  • increased blood bilirubin

What Are Possible Side Effects of Kalydeco?

Common side effects of Kalydeco include:

  • upper respiratory tract infection,
  • headache,
  • stomach pain,
  • nausea,
  • rash,
  • acne,
  • diarrhea,
  • dizziness,
  • joint or muscle pain, or
  • cold symptoms (stuffy nose, sneezing, sore throat).

Serious side effects of Kalydeco include:

What Is Trikafta?

Trikafta (elexacaftor, tezacaftor and ivacaftor tablets; ivacaftor tablets) is a combination of ivacaftor, a CFTR potentiator, tezacaftor, and elexacaftor used to treat cystic fibrosis (CF) in patients aged 12 years and older who have at least one F508del mutation in the CFTR gene. If the patient’s genotype is unknown, an FDA-cleared CF mutation test should be used to confirm the presence of at least one F508del mutation.

What Is Kalydeco?

Kalydeco (ivacaftor) film-coated tablets are a CFTR potentiator indicated for the treatment of a rare form of cystic fibrosis (CF) in patients ages 6 years and older who have the specific G551D mutation in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene.

What Drugs Interact With Trikafta?

Trikafta may interact with other medicines such as:

  • rifampin,
  • rifabutin,
  • seizure medications,
  • St. John’s wort,
  • azole antifungals,
  • macrolide antibiotics,
  • glimepiride and glipizide,
  • digoxin,
  • cyclosporine,
  • everolimus,
  • sirolimus,
  • tacrolimus,
  • statins,
  • glyburide,
  • nateglinide, and
  • repaglinide

Tell your doctor all medications and supplements you use.

What Drugs Interact With Kalydeco?

Kalydeco may interact with:

Tell your doctor all medications and supplements you use.

How Should Trikafta be Taken?

The morning dose of Trikafta for adults and pediatric patients aged 12 years and older is two elexacaftor 100 mg, tezacaftor 50 mg and ivacaftor 75 mg tablets. The evening dose of Trikafta for adults and pediatric patients aged 12 years and older is one ivacaftor 150 mg tablet. The morning and evening doses of Trikafta should be taken approximately 12 hours apart with fat-containing food.

How Should Kalydeco be Taken?

In adults and pediatric patients age 6 years and older, one 150 mg Kalydeco tablet should be given orally every 12 hours with fat-containing food. Dosage of Kalydeco should be reduced when co-administered with moderate and severe hepatic impairment.

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References
Vertex Pharmaceuticals Incorporated. Trikafta Product Information.

trikafta.com

Vertex Pharmaceuticals Incorporated. Kalydeco Product Information.

https://www.kalydecohcp.com/

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