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Trilisate

Last reviewed on RxList: 12/8/2004
Trilisate Side Effects Center

Last reviewed on RxList 1/22/2016

Trilisate (choline magnesium trisalicylate) is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain and inflammation caused by conditions such as arthritis. Trilisate is also used to treat fever in adults. The brand name Trilisate is discontinued, but generic versions may be available. Common side effects of Trilisate (choline magnesium trisalicylate) include upset stomach, heartburn, nausea, vomiting, diarrhea, constipation, dizziness, drowsiness, lack of energy, or headache.

In rheumatoid arthritis, osteoarthritis, the more severe arthritides, and acute painful shoulder, the recommended starting dosage of Trilisate is 1500 mg twice daily. Trilisate may interact with antidepressants, cyclosporine, lithium, methotrexate, blood thinners, medication used to prevent blood clots, oral diabetes medication you take by mouth, diuretics, heart or blood pressure medication, medicines to treat or prevent osteoporosis, seizure medications, steroids, or medicines that contain sodium bicarbonate, sodium citrate, or potassium citrate. Tell your doctor all medications and supplements you use. During the first 6 months of pregnancy, Trilisate should be used only when prescribed. It is not recommended for use during the last 3 months of pregnancy due to possible harm to the fetus and problems with normal labor/delivery. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Breastfeeding is not recommended while using this drug.

Our Trilisate (choline magnesium trisalicylate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Trilisate Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using choline magnesium trisalicylate and call your doctor at once if you have a serious side effect such as:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
  • sudden numbness or weakness, especially on one side of the body;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • blood in your urine, urinating more or less than usual;
  • hearing problems, ringing in your ears;
  • severe stomach pain, ongoing nausea or vomiting, jaundice (yellowing of the skin or eyes);
  • easy bruising or bleeding, unusual weakness; or
  • fast or pounding heartbeats, feeling like you might pass out.

Less serious side effects may include:

  • heartburn, upset stomach, diarrhea, constipation;
  • dizziness, drowsiness, lack of energy; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Trilisate (Choline Magnesium Trisalicylate)

Trilisate Professional Information

SIDE EFFECTS

The most frequent adverse reactions observed with TRILISATE (choline magnesium trisalicylate) preparations in clinical trials (7- 12) are tinnitus and gastrointestinal complaints (including nausea, vomiting, gastric upset, indigestion, heartburn, diarrhea, constipation and epigastric pain). These occur in less than twenty percent (20%) of patients. Should tinnitus develop, reduction of daily dosage is recommended until the tinnitus is resolved. Less frequent adverse reactions, occurring in less than two percent (2%) of patients, are: hearing impairment, headache, lightheadedness, dizziness, drowsiness, and lethargy. Adverse reactions occurring in less than one percent (1%) of patients are: gastric ulceration, positive fecal occult blood, elevation in serum BUN and creatinine, rash, pruritus, anorexia, weight gain, edema, epistaxis and dysgeusia.

Spontaneous reporting has yielded isolated or rare reports of the following adverse experiences: duodenal ulceration, elevated hepatic transaminases, hepatitis, esophagitis, asthma, erythema multiforme, urticaria, ecchymoses, irreversible hearing loss and/ or tinnitus, mental confusion, hallucinations.

DRUG ABUSE AND DEPENDENCE

Drug abuse and dependence have not been reported with TRILISATE (choline magnesium trisalicylate) preparations.

Read the entire FDA prescribing information for Trilisate (Choline Magnesium Trisalicylate)

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