Trimagnesium Citrate Anhydrous

Trimagnesium citrate anhydrous is an over-the-counter (OTC) product used to treat or reduce the risk of low blood magnesium levels (hypomagnesemia) in individuals diagnosed with a cardiovascular condition [e.g., congestive heart failure, high blood pressure (hypertension), tachyarrhythmia, atherosclerosis]; gastrointestinal condition (e.g., Crohn’s disease, ulcerative colitis, celiac disease); electrolyte abnormality [e.g., low blood sodium (hyponatremia), low blood potassium (hypokalemia), low blood calcium (hypocalcemia), low blood phosphates (hypophosphatemia), refractory potassium depletion]; diabetes mellitus; nephrolithiasis; or osteoporosis.

Trimagnesium citrate anhydrous is available under the following different brand names: Magnitria.

Dosages of Trimagnesium Citrate Anhydrous:

Dosage Forms and Strengths

Oral Powder

• 1504mg/powder sachet (elemental magnesium/sachet: 243mg [20mEq])

Dosage Considerations – Should be Given as Follows:

Magnesium Supplementation

• A dietary supplement to treat or reduce the risk of magnesium deficiency
• Dose based on elemental magnesium (Mg) 243-486 mg orally daily
• If 486 mg/day administered, give as 2 doses 4-8 hours apart

Dosing Considerations

• Indication: Recommended to treat or reduce the risk of low blood magnesium levels (hypomagnesemia) in individuals diagnosed with a cardiovascular condition [e.g., congestive heart failure, high blood pressure (hypertension), tachyarrhythmia, atherosclerosis]; gastrointestinal condition (e.g., Crohn’s disease, ulcerative colitis, celiac disease); electrolyte abnormality [e.g., low blood sodium (hyponatremia), low blood potassium (hypokalemia), low blood calcium (hypocalcemia), low blood phosphates (hypophosphatemia), refractory potassium depletion]; diabetes mellitus; nephrolithiasis; or osteoporosis
• 243 mg elemental Mg provides approximately60% of recommended daily intake (RDI)
• RDI for adults is 400 mg/day
• Other ingredients: Xylitol, citric acid, natural and artificial orange flavor, dextrin, sucralose

Administration

• Mix with 4-8 oz of water, stir well, and drink
• May take with or without food
• Store in a dry location at 59-86°F (15-30°C)
• Safety and efficacy not established in pediatric patients

Side effects of trimagnesium citrate anhydrous include:

• Weakness/lethargy
• Dizziness
• Low blood pressure (hypotension)
• Respiratory depression
• Diarrhea
• Abdominal cramping
• Electrolyte imbalance
• High blood magnesium (hypermagnesemia)
• Muscle weakness

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

• Trimagnesium citrate anhydrous has no listed severe interactions with other drugs.
• Serious interactions of trimagnesium citrate anhydrous include:
  • baloxavir marboxil
• Trimagnesium citrate anhydrous has moderate interactions with at least 31 different drugs.
• Trimagnesium citrate anhydrous has no listed mild interactions with other drugs.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Check with your physician if you have health questions or concerns.

Warnings

• This medication contains trimagnesium citrate anhydrous. Do not take Magnitria if you are allergic to trimagnesium citrate anhydrous or any ingredients contained in this drug.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

• Known hypersensitivity to proton pump inhibitors (PPIs)
• Gastrointestinal (GI) obstructions
• High blood magnesium (hypermagnesemia)

Effects of Drug Abuse

• No information available

Short-Term Effects

• See "What Are Side Effects Associated with Using Trimagnesium Citrate Anhydrous?”

Long-Term Effects

• See "What Are Side Effects Associated with Using Trimagnesium Citrate Anhydrous?”

Cautions

• Kidney dysfunction
• Patients who experience a sudden change in bowel habits
• Coadministration with calcium channel blockers (CCBs); magnesium may enhance the hypotensive effect of the calcium channel blockers
• May enhance the neuromuscular-blocking effect of neuromuscular-blocking agents
• Avoid concomitant use of calcium polystyrene sulfonate
• The high fat content of food decreases magnesium absorption

Pregnancy and Lactation

• Trimagnesium citrate anhydrous may be acceptable for use during pregnancy. Either animal studies show no risk but human studies are not available or animal studies showed minor risks and human studies were done and showed no risk. Trimagnesium citrate anhydrous crosses the placenta. A physician should guide the dosage for pregnant women.
• Trimagnesium citrate anhydrous is excreted in human breast milk. Concentrations remain constant during the first year of lactation. The effects of prolonged increments in magnesium are not known.
• Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.