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Trintellix vs. Pristiq

Medical and Pharmacy Editor:

Are Trintellix and Pristiq the Same Thing?

Trintellix (vortioxetine) and Pristiq (desvenlafaxine) are antidepressants used to treat major depressive disorder (MDD).

Trintellix is a selective serotonin reuptake inhibitor (SSRI) and Pristiq is a selective serotonin and norepinephrine reuptake inhibitor (SNRI).

What Are Possible Side Effects of Trintellix?

Common side effects of Trintellix include:

  • nausea
  • diarrhea
  • dry mouth
  • constipation
  • vomiting
  • gas
  • dizziness
  • abnormal dreams
  • itching, and
  • decreased sexual desire

Antidepressants such as Trintellix increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Tell your doctor if you experience any thoughts of suicide while taking Trintellix.

What Are Possible Side Effects of Pristiq?

Common side effects of Pristiq include:

  • increased or excessive sweating,
  • dizziness,
  • drowsiness,
  • dry mouth,
  • constipation,
  • sleep problems (insomnia),
  • loss of appetite,
  • tightness in your jaw,
  • nausea,
  • weight loss,
  • blurred vision,
  • nervousness,
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm.

What is Trintellix?

Trintellix (vortioxetine) tablets are an antidepressant indicated for the treatment of major depressive disorder (MDD).

What is Pristiq?

Pristiq (desvenlafaxine) is type of antidepressant called a selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder.

What Drugs Interact With Trintellix?

Trintellix may interact with monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, buspirone, tramadol, tryptophan products, NSAIDs, aspirin, warfarin, bupropion, fluoxetine, paroxetine, quinidine, rifampicin, carbamazepine, and phenytoin. Tell your doctor all medications and supplements you use.

What Drugs Interact With Pristiq?

Pristiq may interact with cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, medicines for seizures or anxiety, other antidepressants, nonsteroidal anti-inflammatory drugs (NSAIDs), blood thinners, St. John's wort, tramadol, L-tryptophan, heart medications, or medicines to treat migraines.

Pristiq may also interact with diuretics (water pills), linezolid, lithium, metoclopramide, midazolam, antibiotics, antifungals, blood pressure medications, or HIV/AIDS medicines.

How Should Trintellix Be Taken?

The recommended starting dose of Trintellix is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated.

How Should Pristiq Be Taken?

The recommended dose for Pristiq is 50 mg once daily, with or without food.

Reviewed on 10/10/2018

Takeda Pharmaceuticals U.S.A., Inc. Trintellix Product Information
Pfizer. Pristiq Product Information.


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