Triostat Side Effects Center

Last updated on RxList: 2/9/2022
Triostat Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Triostat?

Triostat (liothyronine sodium injection) (T3) is a thyroid hormone preparation indicated in the treatment of myxedema coma/precoma. Triostat can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef. Triostat is available in generic form.

What Are Side Effects of Triostat?

Common side effects of Triostat include:

Dosage for Triostat

An initial intravenous Triostat dose ranging from 25 mcg to 50 mcg is recommended in the emergency treatment of myxedema coma/precoma in adults.

What Drugs, Substances, or Supplements Interact with Triostat?

Triostat may interact with oral anticoagulants, insulin or oral hypoglycemics, estrogen, oral contraceptives, tricyclic antidepressants, digitalis, ketamine, and vasopressors. Tell your doctor all medications and supplements you use.

Triostat During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant before receiving Triostat. Thyroid hormones do not readily cross the placental barrier and in general, thyroid replacement therapy to hypothyroid women should not be discontinued during pregnancy. Minimal amounts of Triostat pass into breast milk. Thyroid hormones such as Triostat are not generally associated with serious side effects. Consult your doctor before breastfeeding.

Additional Information

Our Triostat (liothyronine sodium injection) (T3) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Where is the thyroid gland located? See Answer
Triostat Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using liothyronine and call your doctor if you have symptoms of thyroid toxicity, such as chest pain, fast or pounding heartbeats, feeling hot or nervous, or sweating more than usual.

Also call your doctor at once if you have:

  • weak or shallow breathing;
  • confusion;
  • a feeling of being cold all the time;
  • changes in weight or appetite;
  • chest pressure spreading to your jaw or shoulder;
  • a light-headed feeling, like you might pass out;
  • severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes;
  • a seizure; or
  • (in a child or teenager) pain, stiffness, and trouble moving the legs.

Common side effects may include:

  • trouble breathing;
  • headache;
  • tremors, feeling nervous or irritable;
  • muscle weakness;
  • increased appetite;
  • diarrhea;
  • irregular menstrual periods;
  • weight loss;
  • feeling hot;
  • rash; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Hyperthyroidism Symptoms and Treatment See Slideshow
Triostat Professional Information


The most frequently reported adverse events were arrhythmia (6% of patients) and tachycardia (3%). Cardiopulmonary arrest, hypotension and myocardial infarction occurred in approximately 2% of patients. The following events occurred in approximately 1% or fewer of patients: angina, congestive heart failure, fever, hypertension, phlebitis and twitching.

In rare instances, allergic skin reactions have been reported with liothyronine sodium tablets.

For medical advice about your adverse reactions contact your medical professional. To report SUSPECTED ADVERSE REACTIONS, contact JHP at 1-866-923-2547 or MEDWATCH at 1-800-FDA-1088 (1-800-332-1088) or

Read the entire FDA prescribing information for Triostat (Liothyronine Sodium Injection)

© Triostat Patient Information is supplied by Cerner Multum, Inc. and Triostat Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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